王勤教授简介---兰州大学生命科学院 - 生命科学学院 - 弘毅考研论坛 -
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王勤教授简介---兰州大学生命科学院
主题帖子考研币
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近年来主要研究先导化合物对肿瘤细胞分化和凋亡的调控作用;探索天然产物对肿瘤免疫逃逸的干预作用;天然及人工合成功能小分子的生物活性、毒性、肿瘤相关基因的分子生物学、免疫调节、抗肿瘤分子机理及计算机模拟药物定量构效关系分析。
免疫调节的分子机理研究。
具生物活性的先导化合物的生物活性和构效关系及计算机辅助设计与筛选。
以NF-kB为靶点的抗肿瘤先导化合物的高通量筛选
经历: 8.7 化学系高分子化学专业学习
1.7 四学生物系生物化学专业进修
3.10 中科院上海生化所 高级生化进修班
4.7 北京语言大学 出国外语培训
5.11 法国巴黎第七大学 公派访问学者
科研、工作经历:
5.7 兰州大学生物系生物化学专业任助教
3.2 兰州大学生物系生物化学专业 讲师
3.11 兰州大学生命科学学院 副教授
2003.12至今 兰州大学生命科学学院 教授发表论文：
Yin Han,Qin Wang*,Yu-Ping Du,Ming-Hua Lv and Xin-Ping Hui Synthesis and Antiproliferative Activity of 6-Ferrocenyl-3-substituted 7H-1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazines Journal of the Chinese Chemical Society, 4-218
Ruidong Miao,Yin Han,Lizhe An,Jinbo Yang,**, Qin Wang*. Seleno-podophyllotoxin derivatives induce hepatoma SMMC-7721 cell apoptosis through Bax pathway Cell Biology International 32 (3
Ruidong Miao,Juan Wei,Qi Zhang,Venkateswara Sajja,Jingbo Yang**,and Qin Wang,*Redifferentiation of human hepatoma cells (SMMC-7721) induced by two new highly oxygenated bisabolane-type sesquiterpenes (HOBS)Journal of Biosciences. 2008; 33（5):723-730.
Ruidong Miao,Xiaohui Xia,Dongling Yang,Minghua Lu,Qin Wang* Apoptosis induced by3,7-dinitrodibenzobromonium salts inK562 cells Front. Biol. China Higher Education Press and Springer-Verlag 2008
Chen Ying,Meng Xueqin,Du Yuping,Zhang Qi,Zhu Ying Wang Qin* Highly oxygenated Bisabolane-type sesquiterpenes induced human hepatoma SMMC-7721 cells apoptosis Journal of Lanzhou University (Natural Sciences) ):49-54
Huan Wang,Huanhuan Gao,Qin Wang, Qingxiang Gao,Changjun Lin Specific anticancer activity of a new bisabolane sesquiterpene against human leukemia cells inducing differentiation in vitro Pharmazie 62: 699–704 (2007)
Zhang Xingwang, Wang Qin ,Liu Jixing, et al. Cloning of whole ORF coding genes of FMDV and construction of recombinant adenoviral pAdTrack-CMV Veterinary Science in China ):93297
Zhang Xingwang, He Lili,Wang Qin Enhanced effect of Dicranostigma Leptopodum(Maxim.)Fedde on experimental immunosuppression in mice Journal of Lanzhou University (Natural Sciences) ):55-57
Bao-dui Wang, Zheng-Yin Yang*, Qin Wang,Ti-kuan CaianPatrickCrewdson Synthesis,characterization, cytotoxic activities, and DNAbinding properties of the La(III) complex with Naringenin Schiff-base Bioorganic & Medicinal Chemistry 14 (–1888
Qi Zhang,Jing Pan, Qin Wang* Redifferentiation of human hepatoma cell induced by 6-(p-chlorophenyl)-3-[1-(p-chlorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl] -s- triazolo [3,4-b]-1,3,4-thiadiazole (TDZ). Pharmazie, ):378-382.
Wang Qin,Yu-Ping Du,PengFei Xu,Zaozao Qiu,HaiRong Xia,BoTao Fan. QSAR and Computer-aided Drug Design of Anti-Bacterial Compounds Based on Benazepine and β-D-Glucopyranoside Analogs. 3rd INTERNATIONAL SYMPOSIUM.CMPTI-2005.
Yan Wang, Zheng-Yin Yang. Qin Wang. Crystal structure, antitumor activities and DNA-binding properties of the La(III) complex with Phthalazin-1(2H)-one prepared by a novel route. Journal of Organometallic chemistry. 690(63.
Zhang Qi,Guo Guoning,Miao Ruidong,Chen Nengyu,Wang Qin* Studies on the chemical constituents of Artemisia Sieversiana and their anticancer activities Journal of Lanzhou University (Natural Sciences) ):68-71
齐蕊 王勤. Fas/Fas L 系统对肿瘤细胞凋亡失效的研究进展. 国外医学肿瘤学分册. 2004年. 31卷. 增刊.
Wang Qin,Zhao Qi,Wang Shufang,He Yonggang,Hui Xinping,Zhang Ziyi Antibacteria effect and structure-activity relationship of cephalosporin derivatives Journal of Lanzhou University (Natural Sciences) ):77-79
ZHANG Qi,WANG Qin,HAN Yin,HE Yong-Gang,HUI Xin-Ping. STUDY ON ANTIBACTERIA ACTIVITY OF S-THIAZOLO-[3, 4-b]-1,3,4-THIADIAZINE DERIVATIVES AND STRUCTURE ACTIVITY RELATIONSHIPS. ACTA MICROBIOLOGICA SINICA. ):61.
毛丽敏，王菊芳，王勤* 细胞的间隙连接 国外医学肿瘤分册，）: 264
ZHANG Qi,WANG Qin, CHEN Zheng-Shan. In vitro antibacterium and antitumor activities of sesquiterpenes compound from cremanthodium discoideum Msxim. 　Chinese Pharmacological Bulletin 　):597
ZHANG Qi,WANG Qin, MIAO Rui-dong, WANG Fang. INHIBITION OF NOVEL HIGHLY OXYGENATED BISABOLANCE SESQUITERPENE COMPOUNDS FROM CREMANTHODIUM DISCOIDEUM ON THE GROWTH OF HUMAN HEPATOMA CELL LINE SMMC-7721.Acta Pharmaceutica Sinica ):993-995
Xin-Ping,Hui,Lin-Mei Zhang,Zi-Yi Zhang,Qin Wang, et al. Syntheisis and Antibacterial Activity of 3-(5-Methylisoxazol-3-yl) 1, 2, 4-thiadiazine Derivatives. Chinese Journal of Chemistry 1 Wang Shufang,Wang Qin,Pan Jing, Zhang Yan, and Zhang Ziyi Anti-oxidation effects of pyrrolin nitroxides and derivatives in tissues and red blood cell from rats in vitro.　Chinese Pharmacological Bulletin 　) :427～31
CHEN Zheng-shan,WANG Qin.Effects of polyethylene glycol on cell growth and taxol production in suspension cultures of Taxus cuspidata. Acta Botanica Boreali-Occidentalia Sinica.): 257—261
WANG Fang, WANG Qin, JIANG Zhi-jun.Inositol Hexaphosphate Induces the Changes of MDA Content in Different Organs and SOD Activity in Red Cells of S180 Rats. J.of Chinese Microcirculation Mar. 2001,Vol.5,No,1
20.王芳，王勤* 蒋志军 等 磷酸肌醇对S180小鼠瘤体微循环的影响 中国微循环): 108
MAO Ai-hong, ZHANG Yu, ZHAO Qi, WANG Qin,WANG Ting-pu. Protective effect of dicranostiga leptodu (Maxim.)Fedde on immunological live injury in mice.Chinese Pharmacological Bulletin　):940～3 ZHAO Qi, XIAO Jie, WANG Qin. Effect of Pleurotus ferulae on Immune Function in Mice. EDIBLE FUNGI OF CHINA.　2001,Vol.20, No.1:43
Xin-Ping,Hui,Lin-Mei Zhang,Zi-Yi Zhang,Qin Wang, et al Heterocylic Systems Containing Bridged Nitrogen Atom: Synthesis and Antibacterial Activity of 3-(2-Phenylquinolin-4-yl)/3-(1-p-chlorophenyl-5-methyl-1,2,3-triazol-4-yl)-s-triazolo[3,4-b]-1,3,4-thiadiazine derivatives Journal of the Chinese Chemical Society 2000. 47 : 1115
Wang Qin,Wang Fang,Yang Jinbao,et al The Antioxidization effects of TP-5, Thya1 [lys23] and Their Spin Labled Derivatives China J pharm sci ):182
Yan Zhang,Xiao-Wen Sun,Zi-Yi Zhang,Qin Wang,et al Synthesis of N-(1-oxyl-2,2,5,5-tetramethylpyrrolin-3-yl)-N’-(3-aryl-5-ercapto-1,2,4-triazol-4-yl)ureas and N-(3-aryl-5-mercaptor-1,2,4-triazol-4-yl)-(1-oxy1-2,2,5,5-tetramethylpyrrolin-3-yl) acid amide. Journal of the Chinese chemical society 2000,47：1263
Xin-Ping,Hui,Lin-Mei Zhang,Zi-Yi Zhang,Qin Wang, et al Synthesis and Antibacterial Activity of S-Triazoles, S-Triazolo [3,4-b]-1,3,4- Thiadiaz- ines and S-Triazolo[3,4-b]-1,2,4-thiadiazoles of 5-methylisoxazole. Journal of the Chinese chemical society 2000, 47：535
Wang Qin, Wang Shufang, Gao Liwei.Activity of Immune Regulation of Growth Hormone Releasing Peptide(GHRP) on Enhanced Growth of Mice. Journal of Lanzhou University (Natural Sciences).2000,Vol.36 No.4:69
王勤 讲授《生物化学》十多年的探索与实践 高等理科教育
Xiao-Wen Sun,Yan Zhang,Zi-Yi Zhang,Qin Wang,et al Studies on Condensed HeterocyclicCompounds:6-(1-aryl-5-methyl-1,2,3-triazol-4-yl)-3-(4-pyridyl)-s-triazolo[3,4-b]-1,3,4-thiadiazoles. Indian Journal of Chem 1999. 38(B): 380
Xiao-Wen Sun,Yan Zhang,Zi-Yi Zhang,Qin Wang,et al Synthesis and antibacterial of 1,3,4-thiadiazole, 1,3,4-oxadiazole and 1,2,4-triazole derivatives of 5-methylisox-azole. India J Chem 1999. 38(B): 679
Xin-Ping,Hui,Lin-Mei Zhang,Zi-Yi Zhang,Qin Wang, et al Sythesis and antibacterial activity of 4-ary1-1- (1-p-chlorophenyl-5-methyl-1,2,3-triazol-4-carbony1) thiosemicarbazides and their related heterocylilc derivatives India J Chem 1999. 38(B): 1066Xiao-Wen Sun,Yan Zhang,Zi-Yi Zhang,Qin Wang,et al Studies on Condensed Hetercyclic Compounds. XX. Synthesis and Antibacterial Activity of Novel 6-Ary1-3-(1-p-chlorophenyl-5-methyl-1,2,3-triazol-4-yl)-s-triazolo[3,4-b]-1,3,4-8. Xin-Ping,Hui,Lin-Mei Zhang,Zi-Yi Zhang,Qin Wang, et al Sythesisandantibacterial activity of 4-ary1-1-(1-p-chlorophenyl-5-methyl-1,2,3-triazol-4-carbony1) thiosemicarbazides and their related heterocylilc derivatives India J Chem 9
Wang Qin,et al. The antioxidization effects of TP-5 active fragment of Thyα1and their spin labelled derivatives International Chinese Peptide Symposium
Wang Qin,et al. Antilesion effect of Thymosinα1 and its spin labeled analog. International Chinese Peptide Symposium
学术团队：（在校） 学术团队：（已毕业）
姓名年级 联系方式备注苗瑞东2001　韩寅2001　毛爱红2002.cn甘肃医学科学院肿瘤研究所杨东玲1995中科院生物物理研究所王书芳1997兰州大学生科院赵祈2000zhaoq@　张琪1999　美国华盛顿大学陈正山1998　　王芳1996　东学生命科学学院齐蕊2003　河南省人事厅夏小惠2003北京体育大学王明辉2003　中科院生物物理研究所陈瑛2005甘肃卫生防疫研究所魏娟2005甘肃省农业大学王燕玲2002中科院兰州近代物理研究所张兴旺2001甘肃省人民医院临床免疫室杨洋2004兰州大学化学化工院杜宇平2004兰州大学生科院蔡体宽2004　张萍2003巴黎第十一大学攻读博士学位李宁2003中科院兰州近代物理研究所
姓名年级 联系方式备注高笑菲2006　王文第2006　蒋 鹏2007　蒋 威2007　吕明华2007　徐锡明2007　袁 卿2007　赵 阳2007　海 军2008　王 芳2008　张文华2008　杜宇平　duyp07@实验师苗瑞东　.cn讲师
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四丁基氟化铵(TBAF)促进的β-卤代-α,β-不饱和醛_酮的一些新反应和氟代反应就研究
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