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求翻译：inhibitor of nuclear factor kappa-B kinase是什么意思？
inhibitor of nuclear factor kappa-B kinase
问题补充：
核因子kappa -B激酶抑制剂
核因素KappaB激酶抗化剂
核因素kappa-B激酶抗化剂
核因子 κ B 激酶抑制剂
核因素 kappa-B 的抑制剂 kinase
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& Human Nuclear factor NF-kappa-B p100 subunit(NFKB2) ELISA kit
Human Nuclear factor NF-kappa-B p100 subunit(NFKB2) ELISA kit
no[provided by RefSeq]
MGI1099800
OMIM164012
CUSABIOCSB-EL015760HU
产品类型:ELISA Kit
产品名称:Human Nuclear factor NF-kappa-B p100 subunit(NFKB2) ELISA kit
英文名称:Human Nuclear factor NF-kappa-B p100 subunit(NFKB2) ELISA kit
CSB-EL015760HU
LYT-10, LYT10, p52, OTTHUMP|nuclear factor of kappa light chain gene enhancer in B-cells 2|nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
待测物名称:
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
蛋白功能1:
Transcription/Transcription regulation
蛋白功能3:
Transcription
25 pg/ml-1600 pg/ml
所需样本体积:
standard curves are provided for demonstration only. A standard curve should
be generated for each set of samples assayed.
Intra-assay Precision (Precision within an assay):
samples of known concentration were tested twenty times on one plate to
Inter-assay Precision (Precision between assays): CV%<10%
samples of known concentration were tested in twenty assays to assess.
assess the linearity of the assay, samples were spiked with high
concentrations of human NFKB2 in various matrices and diluted with the Sample
Diluent to produce samples with values within the dynamic range of the assay.
Serum(n=4)
recovery of human NFKB2 spiked to levels throughout the range of the assay in
various matrices was evaluated. Samples were diluted prior to assay as
directed in the Sample Preparation section.
Sample Type
Average % Recovery
Serum (n=5)
EDTA plasma (n=4)
酶联免疫试剂盒重组蛋白多克隆抗体RT-PCR引物
Copyright&&&&&&nbsp鄂ICP备号-3INTRODUCTION Organ failure 15 eommon in Patients with severe aeute Panereatitis(SAP)，and Patients with multiPle organ dysfunction (MODF)and aeute resPiratory distress syndrome(，、RDS)have a higherlllortalltyrate.PI℃ventionandaetivetrea恤entoforgan failul℃ean imProve the OLltcome ofPatientswithS了甲[l].Reeent studies have demonstrated that SAP comPlieatelj by ARDS and MODF 15 hardly elueidated by the traditional coneePts of Pancreatic enzyme activation and autodigestion，but elosely associated with some cytokilles such as TNFa，IL一1;。d，IL一8碑，3]. At Present，researehers Pay more attention to the relationshiP between nuelear faetor kaPPa一B(NF一KB)，intlammatory cytokines and aeute Pancreatitis(AP)[2，4].NF一沼15 a protein that ean ...
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The nuclear factor kappa B signaling pathway
ThenuclearfactorkappaBsignalingpathway:integratingmetabolismwithinflammation
LauraTornatore,AnilK.Thotakura,JasonBennett,MartaMoretti,andGuidoFranzoso
SectionofInflammationandSignalTransduction,DepartmentofMedicine,ImperialCollegeLondon,HammersmithHospitalCampus,DuCaneRoad,LondonW120NN,UK
NuclearfactorkappaB(NF-kB)transcriptionfactorsareevolutionarilyconserved,coordinatingregulatorsofim-muneandinflammatoryresponses.Theyalsoplayapivotalroleinoncogenesisandmetabolicdisorders.SeveralstudiesduringthepasttwodecadeshavehighlightedthekeyroleoftheIKK/NF-kBpathwayintheinductionandmaintenanceofthestateofinflamma-tionthatunderliesmetabolicdiseasessuchasobesityandtype2diabetes.Recentreports,however,revealanevenmoreintimateconnectionbetweenNF-kBandmetabolism.ThesestudiesdemonstratethatNF-kBreg-ulatesenergyhomeostasisviadirectengagementofthecellularnetworksgoverningglycolysisandrespiration,withprofoundimplicationsbeyondmetabolicdiseases,includingcancer,ageingandanticancertherapy.Inthisreview,wediscusstheseemergingbioenergeticfunc-tionsofNF-kBandtheirsignificancetooncogenesis.
Integrationandcoevolutionofimmuneandmetabolicsystems
NF-kBisbestknownforitsfunctionsinimmunity,inflam-mation,andoncogenesis[1–4].Severalstudiesduringthepastfewyearshaveunderscoreditscentralroleinmeta-bolicpathologies[5–7].ThisinvolvementofNF-kBinmetabolismandinflammationappearstoreflectthecloseintegrationandcoevolutionofnutrient-andpathogen-sensingsystems[6].Theabilitiestoendurestarvationandmountaneffectivedefenseagainstinfectionareamongthemostbasicrequirementsforspeciessurvival[6].Mountingaprotectiveimmuneresponse,however,isbioenergeticallycostly[5–7].Thus,fromametabolicper-spective,theneedtoprotecttheorganismfrompathogenscompeteswiththeneedtomaintainmetabolichomeostasis[6].Thispresentsafundamentalphysiologicalchallenge,whichhasbeenmetinevolutionthroughthecloseintegra-tionandcoordinationofimmuneandinflammatoryresponseswiththeregulationofmetabolism[6].
Thisconceptiseloquentlyillustratedbytheanatomicalcolocalizationofkeyconstituentsoftheimmuneandmet-abolicsystemsinlowerorganisms[6].InDrosophilamel-anogaster,immuneandmetabolicfunctionsarecontrolledbythesameorgan,thefatbody,whichisequivalenttothe
mammalianliverandadiposetissue,andalsothehemato-poieticandimmunesystems[6](Figure1).Theintimateassociationbetweenmetabolismandinflammationisalsoevidentinthearchitecturalorganizationofmetabolicorgans,suchastheliverandadiposetissue,inhigherorganisms.Here,macrophagesandotherimmunecellsareincloseproximitytometaboliccells,namelythehepa-tocytesandadipocytes[6](Figure1).Adipocytesandmacrophagesalsosharemanypathwaysandsignalingmodules[6],includingpattern-recognitionreceptorssuchasToll-likereceptors(TLRs),whichinduceimmunityandinflammationinresponsetopathogen-associatedproductsanddangersignals[8,9](Figure1).Notably,TLRfamilyreceptors,suchasTLR2andTLR4,whichrecognizelipo-proteinsandlipopolysaccharidesinbacterialwalls,alsosensenutritionalsignalssuchasfattyacids[5–7,10].Reciprocally,signalingpathwaysthataretraditionallyassociatedwithmetabolismcanaffectimmuneresponses(Figure1);metabolichormonessuchasleptinandadipo-nectinalsoregulateimmunefunctions[6,11]andlipid-sensingnuclearreceptorssuchasperoxisomeproliferatoractivatedreceptor(PPAR)andliverXreceptor(LXR)familymemberscansuppressinflammation[6].Theendo-plasmicreticulum(ER)isanothercrucialsitewheremet-abolicandinflammatorypathwaysconverge[5–7,12].Hence,nutrientscaninduceinflammatoryresponsesandpathogenscanevokeandregulatemetabolicsystems[6].Thisbiologicalconfigurationisparamountforthemainte-nanceofenergyhomeostasisandproperfunctioningoftheimmunesystem,butalsorepresentsamajorpredisposingfactorfortheonsetofmetabolicdiseases[5–7].
Correspondingauthor:Franzoso,G.(g.franzoso@imperial.ac.uk).
Keywords:NF-kB;cancer.
Theinflammatorybasisofmetabolicdiseases
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/$–seefrontmatterss2012ElsevierLtd.Allrightsreserved.http://dx.doi.org/10.1016/j.tcb.TrendsinCellBiology,November2012,Vol.22,No.11557
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