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姓名：黎一鸣
目前身份：
担任导师情况：
学术头衔：
博士生导师
学科领域：
研究兴趣：主要从事肝胆外科、胃肠外科、腹部创伤、器官移植等工作。
　黎一鸣，男， 1957年2月出生，教授，博士生导师。1982年毕业于西安医科大学医疗系，分配至西安医科大学附属二院（现为西安交通大学第二医院）工作，历任住院医师、主治医师、副教授，95年任教授至今。1988年获得医学硕士学位。1991年3月至1992年9月在美国哈佛大学医学院访问学习，获Special Fellowship 证书。现主要从事肝胆外科、胃肠外科、腹部创伤、器官移植等工作。从医二十余年，积累了较丰富的外科临床、教学和科研工作经验，率先在我院开展了远端脾肾分流术、“H”型肠腔分流术、“个体化方案”治疗急性重症胰腺炎、分流加断流术治疗门静脉高压症等难度较高的术式，并在我院成功的实施了首例肝脏移植术。主要的临床科研方向为器官移植、肝胆胰疾病，其中课题“肝动脉缺血对供肝及胆道组织损伤机制及防治方法”、“多因素联合评价病肝储备功能”的研究结果已达到国际先进水平。已培养硕士研究生15名，毕业10名，协助培养博士研究生7名。　　共获省部级科研资助课题5项，获得科研基金共20余万元。获得省部级科技进步奖四项，其中二等奖两项、三等奖二项，省教委科技进步一等奖一项。共发表各类学术论文60余篇，主（副主）译译著二部、副主编专著一部、参编专著三部。　　现任西安交通大学第二医院党委委员，外科教研室主任，普通外科主任；中华医学会第十四届外科学会委员，中华医学会创伤学会常委，中华医学会陕西普外学会副主任委员；陕西腔镜外科学会副主委；陕西省有突出贡献的中青年专家、陕西省“215工程”第一梯队人员、陕西省“三五人才”、教育部认定的全国高校骨干教师。
Yi-Ming Li，
Wen-Tao Gao，
Tuan-Jie Lei，
Gui-Bing Ren，
Zhi-Lan Bai，
World J Gastroenterol ): ，-0001，（）：
-1年11月30日
functional reserve of cirrhotic liver by combination of hepatic functional blood flow, liver volume, and Child-Pugh's classification, and to discuss its value of clinical application.
中华普通外科杂志，）：79～81，-0001，（）：
-1年11月30日
建立国人正常肝脏体积计算公式，探讨肝脏体积变化在评价病肝储备功能方面的临床意义。方法
本研究采用螺旋CT 对280 名正常人、85例肝硬化患者进行了腹部扫描并求出其肝脏体积。使用直线相关和回归的方法研究正常人群肝脏体积与体表面积的关系，得出相应的回归方程。求出肝硬化患者肝脏体积的变化率，分析其与Child肝功能分级和术后并发症之间的相互关系。结果
正常成年人肝脏的平均体积为（）cm3，其与体表面积呈正相关关系，相关系数为0.96，回归方程为LV（cm3=613×BSA m2）+162.8。对于肝硬化患者，在Child A级肝脏平均体积为（）cm3，Child B级为（868±163）cm3，Child C级为（652±76）cm3，三者之间差异均存在着显著意义（P&0.001）。Child B级和Child C级与正常组比较，肝脏平均体积明显减小（P&0.001）。当病肝体积缩小40%以上时，术后并发症发生率明显增高。肝脏体积变化率与Child 肝功能分级间存在着交错现象。结论
CT测量方法结合成人正常肝脏体积公式运算，能定量评价病肝体积变化，从而有助于客观评价病肝储备功能状况。
体积描记术，
肝功能试验
肝脏，）：20～27，-0001，（）：
-1年11月30日
探讨肝动脉缺血（HAI）对肝脏组织损狎的影响及基机制。方法
将家兔按有无再灌注后HAI分为HAI组和照组。在兔肝自体原位移植模型基础上，应用原位未端标记（TUNEL）技术、兔疫组化法和硝酸还原酶法，检测肝细胞凋忘指数（AI）、bcl-2蛋白表达和肝组纪念品中一氧化氮（NO）生成水平。结果
HAI组再灌注后各时点肝细胞AI均高于对照组；bcl-2蛋白表达阳性细胞再藻注后较灌注后较灌注前增多、但HAI组对照组比较，各时点均无明显差异（P&0.05）;再灌注后NO浓度较灌注前降低，而且再灌注时期HAI组明显低于对照组（P&0.05）。结论
HAI可通过进一步降低缺血再灌注后NO水平而加重肝细胞凋忘损伤，阻碍供肝功能的恢复，是移植术后供肝功能不全和并发病发生的关键因素之一。
西安交通大学学报（医学版），）：393～394，-0001，（）：
-1年11月30日
探讨肝动脉缺血（HII）过程中氧自由基对肝细胞凋亡的影响及其机制。方法
将家兔按再灌注后有无HAl分为HAI组和对照组。在兔肝自体原位移植模型基础上，应用原位末端标记（TUNEL）技术、免疫组化法和比色法，检测肝细胞凋亡指数（AI）、bcl 2蛋白表达和肝组织中MDA生成水平。结果
随着HAI时司的出现和延长，肝细胞凋亡指数增大。当HAI 3 h时，HAI组凋亡指数增高为12 5%±1 38%，与同组H|、I 30m小HAI 2h和对照组的AI值比较均有显著性升高（P&0.05）。bcl 2蛋白表达阳性细胞于再灌注后增多，但HAI组与对照组比较，各时点均无明显差异。同时，肝组织内MDA含量逐渐增多，HAI组HAI 3h达到最高，同组HAI各时点的MD、含量比较均有显著性差异（P&0.05）。结论
HAI损伤可通过进一步促进缺血再灌注后氧自由基的生成而加重肝细胞凋亡的发生，阻碍供肝功能的恢复，是肝移植后供肝功能不全和并发症发生的关键因素之一。
细胞凋亡，
西安医科大学学报，）：265～269，-0001，（）：
-1年11月30日
通过动物实验研究D-山梨醇体内的药代动力学，评价其在测量正常和肝硬化肝脏的肝功能性血流量、肝内分流率方面的合理性，并探讨其临床应用价值和方法。方法
雄性SD大鼠60只，分为肝硬化组（40只）和正常对照组（20只)，持续静脉滴注D一山梨醇后，在不同时间分别采血和收集尿液，采用酶分光光度法测量山梨醇血浓度和尿浓度，计算正常大鼠和肝硬化大鼠的山梨醇整体清除率（CLTOTAL)、山梨醇肾清除率（CLTOTAL)，从而得出山梨醇肝清除率（CLREN）。然后剖腹测量门静脉压(PVP)，同时制作肝脏隔离灌注模型，采用含山梨醇0.395mmoloL的KH液为灌流液，分别测量灌流液和流出液的山梨醇浓度，计算出肝摄取率(E)、肝总血流量（QTOTAL）和肝内分流率（RINS）。结果
①静脉滴注山梨醇，120min后达稳态血药浓度，正常组（0.209±0.043）mmoloL，肝硬化组（0.334±0.07）mmoloL。⑦正常大鼠PVP=（0.94±0.19）kPa；E=（901±72）%；CLTT=(34 06±5 12mLomin；QTOTAL=（37.8±5.44）mLomin；RM=(99±14)%。③肝硬化大鼠PVP=（1.56±0.37）kPa；E=（63.8±9.8）%；CLII=（21.31±7.02）mLomin；Qlli，I=（33.41±9.71）mLomin；RM=（36.2±9.6）%。④两组相比，肝硬化组PVP和肝内分流率升高；QTOTAL无显著差异；肝摄取率E和肝清除率CL明显下降。结论
采用稳态滴注方法可以无创测定山梨醇肝清除率CLH，是评价正常肝脏或肝硬化肝脏功能性血流量和肝内分流率的一种实用而可靠的方法。
D-山梨醇，
肝血流量，
陕西医学杂志，）：634～636，-0001，（）：
-1年11月30日
采用螺旋CT对280例正常人进行了腹部扫描。通过计算机计算出每地层的体积，再用叠加法求出整个肝脏体积。使用直线相关和回归的方法研究正常人群肝脏体积与身高、体重、体表面积、年龄的关系，求出相应的相关系数、回归方程。结果：正常成年人肝脏的平均为±141.0cm3，其与体表面积、身高、体重是正相关，相关系数分别为0.96、0.90、0.79。年龄、性别对成人肝脏体积大小的影响无显著性。由体表面积推导正常人群标准肝脏体积公式为：LV (CM3)=613×BSA (m2+162.8)。提示：结合CT测量和标准肝体积公式运算后所获得得的资料，能客观地定量评价病肝体积的变化情况。
解剖学和组织学&#47，
放射照像术 断层摄影术&#44，
X线计算机 对比研究
医安医科大学学报，）：126～128，-0001，（）：
-1年11月30日
了解吲哚氰绿排泄试验评估肝储备功能及在分流加断流术(联合术)适应证的选择，确定手术时机中的应用价值。方法通过吲哚氰绿排泄试验与常规方法比较，结合临床资料及术后并发症分析，确定这一方法在评估肝储备功能中的作用。结果当血浆吲哚氰绿15min潴留率（ICGK18）小于20%，可实施联合术；而当ICGK大于25%，特别是病肝明显缩小者，不宜施行联合术。结论吲哚氰绿排泄试验能够更为客观的反映病肝储备功能，对外科术式的选择、手术时机的确定有一定的作用。
肝储备功能，
吲哚氰绿排泄试验，
门静脉高压症，
分流加断流术
中华普通外科杂志，）：79～81，-0001，（）：
-1年11月30日
建立国人正常肝脏体积计算公式，探讨肝脏体积变化在评价病肝储备功能方面的临床意义。方法
本研究采用螺旋CT 对280 名正常人、85例肝硬化患者进行了腹部扫描并求出其肝脏体积。使用直线相关和回归的方法研究正常人群肝脏体积与体表面积的关系，得出相应的回归方程。求出肝硬化患者肝脏体积的变化率，分析其与Child肝功能分级和术后并发症之间的相互关系。结果
正常成年人肝脏的平均体积为（）cm3，其与体表面积呈正相关关系，相关系数为0.96，回归方程为LV（cm3=613×BSA m2）+162.8。对于肝硬化患者，在Child A级肝脏平均体积为（）cm3，Child B级为（868±163）cm3，Child C级为（652±76）cm3，三者之间差异均存在着显著意义（P&0.001）。Child B级和Child C级与正常组比较，肝脏平均体积明显减小（P&0.001）。当病肝体积缩小40%以上时，术后并发症发生率明显增高。肝脏体积变化率与Child 肝功能分级间存在着交错现象。结论
CT测量方法结合成人正常肝脏体积公式运算，能定量评价病肝体积变化，从而有助于客观评价病肝储备功能状况。
体积描记术，
肝功能试验
Yi-Ming Li，
Wen-Tao Gao，
Tuan-Jie Lei，
Gui-Bing Ren，
Zhi-Lan Bai，
World J Gastroenterol ): ，-0001，（）：
-1年11月30日
functional reserve of cirrhotic liver by combination of hepatic functional blood flow, liver volume, and Child-Pugh's classification, and to discuss its value of clinical application.
西安医科大学学报，）：265～269，-0001，（）：
-1年11月30日
通过动物实验研究D-山梨醇体内的药代动力学，评价其在测量正常和肝硬化肝脏的肝功能性血流量、肝内分流率方面的合理性，并探讨其临床应用价值和方法。方法
雄性SD大鼠60只，分为肝硬化组（40只）和正常对照组（20只)，持续静脉滴注D一山梨醇后，在不同时间分别采血和收集尿液，采用酶分光光度法测量山梨醇血浓度和尿浓度，计算正常大鼠和肝硬化大鼠的山梨醇整体清除率（CLTOTAL)、山梨醇肾清除率（CLTOTAL)，从而得出山梨醇肝清除率（CLREN）。然后剖腹测量门静脉压(PVP)，同时制作肝脏隔离灌注模型，采用含山梨醇0.395mmoloL的KH液为灌流液，分别测量灌流液和流出液的山梨醇浓度，计算出肝摄取率(E)、肝总血流量（QTOTAL）和肝内分流率（RINS）。结果
①静脉滴注山梨醇，120min后达稳态血药浓度，正常组（0.209±0.043）mmoloL，肝硬化组（0.334±0.07）mmoloL。⑦正常大鼠PVP=（0.94±0.19）kPa；E=（901±72）%；CLTT=(34 06±5 12mLomin；QTOTAL=（37.8±5.44）mLomin；RM=(99±14)%。③肝硬化大鼠PVP=（1.56±0.37）kPa；E=（63.8±9.8）%；CLII=（21.31±7.02）mLomin；Qlli，I=（33.41±9.71）mLomin；RM=（36.2±9.6）%。④两组相比，肝硬化组PVP和肝内分流率升高；QTOTAL无显著差异；肝摄取率E和肝清除率CL明显下降。结论
采用稳态滴注方法可以无创测定山梨醇肝清除率CLH，是评价正常肝脏或肝硬化肝脏功能性血流量和肝内分流率的一种实用而可靠的方法。
D-山梨醇，
肝血流量，
西安交通大学学报（医学版），）：393～394，-0001，（）：
-1年11月30日
探讨肝动脉缺血（HII）过程中氧自由基对肝细胞凋亡的影响及其机制。方法
将家兔按再灌注后有无HAl分为HAI组和对照组。在兔肝自体原位移植模型基础上，应用原位末端标记（TUNEL）技术、免疫组化法和比色法，检测肝细胞凋亡指数（AI）、bcl 2蛋白表达和肝组织中MDA生成水平。结果
随着HAI时司的出现和延长，肝细胞凋亡指数增大。当HAI 3 h时，HAI组凋亡指数增高为12 5%±1 38%，与同组H|、I 30m小HAI 2h和对照组的AI值比较均有显著性升高（P&0.05）。bcl 2蛋白表达阳性细胞于再灌注后增多，但HAI组与对照组比较，各时点均无明显差异。同时，肝组织内MDA含量逐渐增多，HAI组HAI 3h达到最高，同组HAI各时点的MD、含量比较均有显著性差异（P&0.05）。结论
HAI损伤可通过进一步促进缺血再灌注后氧自由基的生成而加重肝细胞凋亡的发生，阻碍供肝功能的恢复，是肝移植后供肝功能不全和并发症发生的关键因素之一。
细胞凋亡，
医安医科大学学报，）：126～128，-0001，（）：
-1年11月30日
了解吲哚氰绿排泄试验评估肝储备功能及在分流加断流术(联合术)适应证的选择，确定手术时机中的应用价值。方法通过吲哚氰绿排泄试验与常规方法比较，结合临床资料及术后并发症分析，确定这一方法在评估肝储备功能中的作用。结果当血浆吲哚氰绿15min潴留率（ICGK18）小于20%，可实施联合术；而当ICGK大于25%，特别是病肝明显缩小者，不宜施行联合术。结论吲哚氰绿排泄试验能够更为客观的反映病肝储备功能，对外科术式的选择、手术时机的确定有一定的作用。
肝储备功能，
吲哚氰绿排泄试验，
门静脉高压症，
分流加断流术
肝脏，）：20～27，-0001，（）：
-1年11月30日
探讨肝动脉缺血（HAI）对肝脏组织损狎的影响及基机制。方法
将家兔按有无再灌注后HAI分为HAI组和照组。在兔肝自体原位移植模型基础上，应用原位未端标记（TUNEL）技术、兔疫组化法和硝酸还原酶法，检测肝细胞凋忘指数（AI）、bcl-2蛋白表达和肝组纪念品中一氧化氮（NO）生成水平。结果
HAI组再灌注后各时点肝细胞AI均高于对照组；bcl-2蛋白表达阳性细胞再藻注后较灌注后较灌注前增多、但HAI组对照组比较，各时点均无明显差异（P&0.05）;再灌注后NO浓度较灌注前降低，而且再灌注时期HAI组明显低于对照组（P&0.05）。结论
HAI可通过进一步降低缺血再灌注后NO水平而加重肝细胞凋忘损伤，阻碍供肝功能的恢复，是移植术后供肝功能不全和并发病发生的关键因素之一。
陕西医学杂志，）：634～636，-0001，（）：
-1年11月30日
采用螺旋CT对280例正常人进行了腹部扫描。通过计算机计算出每地层的体积，再用叠加法求出整个肝脏体积。使用直线相关和回归的方法研究正常人群肝脏体积与身高、体重、体表面积、年龄的关系，求出相应的相关系数、回归方程。结果：正常成年人肝脏的平均为±141.0cm3，其与体表面积、身高、体重是正相关，相关系数分别为0.96、0.90、0.79。年龄、性别对成人肝脏体积大小的影响无显著性。由体表面积推导正常人群标准肝脏体积公式为：LV (CM3)=613×BSA (m2+162.8)。提示：结合CT测量和标准肝体积公式运算后所获得得的资料，能客观地定量评价病肝体积的变化情况。
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放射照像术 断层摄影术&#44，
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姓名：陈坤
目前身份：在职研究人员
担任导师情况：博士生导师
学位：博士
学术头衔：
博士生导师，
省级人才支持计划入选者
职称：高级-教授
学科领域：
研究兴趣：人群慢性病流行病学；肿瘤分子流行病学；临床流行病学
陈坤，博士，浙江大学医学部公共卫生系主任、教授、博士生导师，为浙江大学公共卫生一级学科负责人兼流行病与卫生统计学二级学科带头人，省151人才第1层次人员，享受国务院特殊津贴。1983年1月至今历任浙江医科大学（1998年10月起为浙江大学医学院）流行病学教研室助教、讲师、副教授、教授；教研室主任，公共卫生系（学院）副主任（副院长）、主任（院长）等职。期间1985年-1986年在美国斯坦福大学医学院，1992年在美国西福吉尼亚医学院，1994年在美国加州伯克利大学任访问学者。
主要研究方向为人群慢性病流行病学、肿瘤分子流行病学和临床流行病学。参加和主持完成20余项科研项目，获成果鉴定和获奖10余项。以第一或通讯作者公开发表论文近200篇，其中SCI收录论文数十篇，国内一级期刊杂志及IM收录论文近百篇。参编全国统编教材《流行病学》和《预防医学》多部，主编出版《医学科研设计原理与方法》、《医学科研方法学》和《临床流行病学》；课题成果鉴定获奖13项，其中国家级2项，省部级6项，厅级5项；已培养研究生14人，在读研究生11人；同时担任中华预防医学会理事；浙江省预防医学会副会长；中华流行病学专业委员会委员；浙江省流行病学专业委员会主任委员；浙江省肿瘤流行病学专业委员会副主任委员；中华医学会临床流行病学分会理事；中国抗癌协会肿瘤流行病学分会常务理事；《中华预防医学杂志》、《中华流行病学杂志》、《浙江大学学报医学版》、《疾病控制杂志》、《海峡预防预防医学杂志》等期刊编委等学术职务。2006年获得第九届&吴阶平医学研究奖&流行病学专业三等奖、2008年获得浙江省预防医学会 优秀科技工作者、2009年获得中华预防医学会流行病学分会中国流行病学优秀奖。
主要研究方向：
1. 传染病与非传染病流行病学：研究遗传多态性、环境暴露及其交互作用在常见恶性肿瘤（结直肠癌、胃癌、肝癌、肺癌和乳腺癌）发病中的作用机制和效应，评价和确定多个肿瘤生物标志物以应用于预测癌症易感人群；研究社会环境因素在传染病与非传染病发生发展中的作用及其防控策略；
2. 管理流行病学：以循证医学和循证公共卫生理论为指导，研究农村公共卫生服务体系建设，开展卫生资源、卫生需求分析与评价及医学数据信息管理与分析研究；
3. 空间流行病学：结合应用地理统计学、生物信息学、地理信息系统（GIS）等方法学，开展环境污染物与慢性非传染性疾病发病的相关性研究。
ZHOU LUN*，
YU HAI+ AND CHEN KUN
BIOMEDICAL AND ENVIRONMENTAL SCIENCES 15, 166-171 (2002)，-0001，（）：
-1年11月30日
Objective To investigate tile association of inicrocystin (MC) in chinking water with the incidence of colorectal cancer. Methods The study was designed as a retrospective cohort. Eight OWnSbips or tOWnS were randomly selected as tile study sites inl Haining City of Zhejiang Province, China. 408 cases of colon and rectum carcinomas diagnosed from 1977 to 1996 in the study sites were included, and a survey on types of drinking water of these patientS was conducted. Samples of different water SOurces (well, tap, river and pond) were collected separately and microcystin concentrations were datemined by indirect competitive ELISA nlethod. Results The incidence rate of colorectal cancel was significantly higher in population who drank river and pond water than those who drank well and tap water. Compared to weU water, the relative risk (RR) for colorectal cancer was 1.88 (tap), 7.94 (river) and 7.70 (pond) respectively. The positive rate (P&50pg/mL) of microcystin in samples of well, tap, river and pond water was 0, 0, 36.23% and 17.14% respectively. Tile concentration of microcystin in river and pond water was significantly tigher than that in well and tap water (P&0.01). Spearman rank conelation analysis showed that in tile study sites, tile inicrocystin concentration of river and pond water was positively associated with the incidence of colorectal cancer (rs=0.881, P&0.01). Conclusions The types of chinking water are positively associated with the incidence of colorectal cancer in the study sites, and tiffs may be related to mcrocystin COlltanination of drinking water. Further biological study is needed to snppolt tile possible Causative role of mycrocystin in carcinogenesis of colon and rectujm.
Drinking watei，
Microcystin，
Colorectalcancer
Li-Ming Sui，
Kun Chcn，
Pai-An Hwang，
Dcng-Fwu Hwang *
，-0001，（）：
-1年11月30日
Study objective: To asses the association between alcohol consumption and the risk of colo-rectal cancer (CRC) in the Chinese population. De-sign: A population-based prospective cohort study was initiated from the colorectal cancer screening population in
Shu Zheng，
Kun Chert，
Xiyong Liu，
Xinyuan Ma，
Kang Chen，
Kaiyan Yao，
Lun Zhou，
* Linbo Wang，
Peiling Qiu，
Yongchuan Deng，
Suzhan Zhang
Dis Colon Rectum, January 2003，-0001，（）：
-1年11月30日
PURPOSE: Colorectal cancer is a major cause of death worldwide. To reduce the incidence and mortality from rectal cancer, an individual quantitative risk-assessment model (hereafter referred to as the Attributive Degree Value) and reverse passive hemagglutination fecal occult blood test were used in a randomized, controlled, populationbased trial that was conducted in Jiashan County, People's Republic of China. METHODS: All residents of Jiashan County aged 30 years or older were enrolled in the study, and 21 townships in the county were randomized to either a screening (n=10 townships) or control (n=11 townships) group. Participants in the screened group submitted a one-article-per-slide stool sample and completed a structured risk-assessment questionnaire from which their attributive degree value was computed. According to study protocol, 4,299 participants were defined as high risk and underwent diagnostic evaluation with 60-cm flexible sigmoidoscopy and, in some cases, an additional screening with colonoscopy. RESULTS: From 1989 to 1996, cumulative mortality from colon cancer was 90 (95 percent confidence interval, 83-97) per 100,000 in the screened group and 83 (95 percent confidence interval, 76-90) per 100,000 in the control group (log-rank 1.49, P=0.222). Mortality from rectal cancer during this time was 110 (95 percent confidence interval, 102-118) per 100,000 in the screened group, which differed significantly from the control group mortality rate of 161 (95 percent confidence interval, 152-170) per 100,000 (log-rank P=0.003). CONCLUSION: Mass screening with a reverse passive hemagglutination fecal occult blood test along with an individual attributive degree value score was effective in reducing mortality from rectal cancer but not in reducing mortality from colon cancer or the incidence of colorectal cancer.
Colorectal neoplasm，
Mass screening，
Randomized&#44，
controlled trial，
Mortality，
LI MING SHUI，
KUN CHEN，
JIAN YUE WANG，
HONG ZHOU MEI，
AI ZENG WANG，
YA-HUI LU，
AND DENG-FWU HWANG，
J. Food Prot., Vol. 66, No.1，-0001，（）：
-1年11月30日
Outbreaks of paralytic snail poisoning have recently occurred in Asia, especially in China. The epidemiological charac-teristics of this disease from an outbreak in Zhoushan City, China, were recorded. Forty-two outbreaks of paralytic snail poisoning, involving 309 cases of illness, occurred from 1977 to 2001. Sixteen people (5.2%) died, 48 people (15.5%) required intubations, and 140 people (45.3%) required emergency hospital treatment as a result of these outbreaks. Outbreaks involved
multiple marine snail species and occurred primarily during the summer (from June to August) on 11 islands with high population densities. Peak numbers of outbreaks and amounts of snail toxicity occurred from 1978 to 1979, from 1985 to 1987, and from 1992 to 1994. Toxicity varied depending on specimen, region, and season. The toxin involved was identified as tetrodotoxin. The data obtained in this study suggest that snails should not be eaten unless they are certified to be nontoxic.
Kun Chen，
Jian Cai，
Xi-Yong Liu，
Xi-Yuan Ma，
Kai-Yan Yao，
World J Gastroenterol ):99-103，-0001，（）：
-1年11月30日
To investigate the risk factors of colon cancer and rectal cancer. METHODS: A nested case-control study was conducted in a cohort of 64 693 subjects who participated in a colorectal cancer screening program from 1989 to 1998 in Jiashan county, Zhejiang, China. 196 cases of colorectal cancer were detected from 1990 to 1998 as the case group and 980 non-colorectal cancer subjects, matched with factors of age, gender, resident location, were randomly selected from the 64 693 cohort as controls. By using univariate analysis and mutivariate conditional logistic regression analysis, the odds ratio (OR) and its 95% confidence interval (95%CI) were calculated between colorectal cancer and personal habits, dietary factors, as well as intestinal related symptoms. RESULTS: The mutivariate analysis results showed that after matched with age, sex and resident location, mucous blood stool history and mixed sources of drinking water were closely associated with colon cancer and rectal cancer, OR values for the mucous blood stool history were 3.508 (95%CI: 1.370-8.985) and 2.139 (95%CI: 1.040-4.402) for the mixed drinking water sources, 2.387 (95%CI: 1.243-4.587) and 1.951 (95 %CI: 1.086-3.506) respectively. All reached the significant level with a P-value less than 0.05. CONCLUSION: The study suggested that mucous blood stool history and mixed sources of drinking water were the risk factors of colon cancer and rectal cancer. There was no any significant association between dietary habits and the incidence of colorectal cancer.
Kun Chen，
Jiong-Liang Qiu，
Yang Zhang，
Yu-Wan Zhao
World J Gastroenterol ): ，-0001，（）：
-1年11月30日
To study the risk factors for colorectal cancer in China. METHODS: A meta-analysis of the risk factors of colorectal cancer was conducted for 14 case-control studies, and reviewed 14 reports within 13 years which included 5034 cases and 5205 controls. Dersimonian and Laird random effective models were used to process the results. RESULTS: Meta analysis of the 14 studies demonstrated that proper physical activites and dietary fibers were protective factors (pooled OR&0.8), while fecal mucohemorrhage, chronic diarrhea and polyposis were highly associated with colorectal cancer (all pooled OR&4). The stratified results showed that different OR values of some factors were due to geographic factors or different resourses. CONCLUSION: Risks of colorectal cancer are significantly associated with the histories of intestinal diseases or relative symptoms, high lipid diet, emotional trauma and family history of cancers. The suitable physical activities and dietary fibers are protective factors.
K. Chen and Y. ZOU
Journal of Pubilc Health 26(2)，-0001，（）：
-1年11月30日
-iodized salt group was 90 g/l, which was lower than 194g/l in the iodized salt group (u=14.673; p＜0.000), whereas the median of daily dirtary iodine intake in the two groups was 128 and 147 ug, respectivel (u=1.847; p=0.065). There was no significant correlation betwwen dietary iodine intake and urinary iodine concentration (P=0.095).
中华消化杂志，）：377～379，-0001，（）：
-1年11月30日
结直肠癌是常见消化道恶性肿瘤之一，谷胱甘肽转移酶（glutathione S-thransferases，GST）是体内重要的Ⅱ相解毒酶家系，参与如多环芳烃、杂环胺等致癌物质的解毒过程，GsT Mu（GsTMl）和GsT Theta（GSTTl）基因缺失会导致相应酶活性的降低[1]。本研究对象来自浙江省嘉善县，采用以人群为基础的结直肠癌随访队列，进行GSTMl和GsTTl基因多态性、饮食与结直肠癌易感性的病例对照研究。
Kun Chen，
Qinting Jiang，
Xinyuan Ma，
Qilong Li，
Kaiyan Yao，
Weiping Yu & Shu Zheng
Accepted in revised form 6 September 2004，-0001，（）：
-1年11月30日
Study objective: To asses the association between alcohol consumption and the risk of colo-rectal cancer (CRC) in the Chinese population. De-sign: A population-based prospective cohort study was initiated from the colorectal cancer screening population in Jiashan County in . The
drinking habits of individuals were investigated with demographic information S A cohort study
was followed-up from 1st Mav 1990 to lst January 2001 and censored at the date of diagnosis of CRC, at death from any causes. or at 1st January 2001. whichever came first. and the person-time was com-
puted Participants: Two hundred and forty two CRC patients were diagnosed during the study period and
64, 100individuals finished the follow-up Results: The distribution of sex, smoking status, occupation, edu-cation 1evel and marital status were a11 significantly different among difierent drinking habits at baseline When the above factors were adjusted, no significant association was observed between alcohol consump-tion and the risk of CRC. Exclusion of individuals diagnosed cancer less than 1 year after the examina-tion date did not alter the strength of an alcoh01 CRC relationship Further analysis in sex strata also did not show a significant relationship Conclusions Alcoh01 drinking may not be associated with a higher risk of CRC in the Chinese population.
Alcohol drinking，
Cohort study，
Colorectal cancer，
Prospective study
中国环境科学，）：41～44，-0001，（）：
-1年11月30日
为探讨乳腺癌发病与有机氯农药污染的关系，采片分阶段整群随机抽样的方法，按乳腺癌标化发病率高低抽取11个乡镇，再随机抽取行政村、自然村，测定再乡镇大米和土壤样品中有机氯各指标的含量，结台各乡镇的乳腺癌发病资料，进行统计分析结果表明，各乡镇的乳腺癌标化发病率存在统计学显著性差异；大米中&-HcH、y-HcH、五氯酚钠以及土壤的&-HcH含量在各乡镇间有显著性差异；乳腺癌标化发病率与大米中PP'-DDD含量呈负相关，相关系数为-0.609，说明经过近20年的降解过程，DDT的衍生物含量最终以PP'-DDD居多，并且乳腺癌标化发痛率与大米中PP'-DDD含量呈负相关。
ZHOU LUN*，
YU HAI+ AND CHEN KUN
BIOMEDICAL AND ENVIRONMENTAL SCIENCES 15, 166-171 (2002)，-0001，（）：
-1年11月30日
Objective To investigate tile association of inicrocystin (MC) in chinking water with the incidence of colorectal cancer. Methods The study was designed as a retrospective cohort. Eight OWnSbips or tOWnS were randomly selected as tile study sites inl Haining City of Zhejiang Province, China. 408 cases of colon and rectum carcinomas diagnosed from 1977 to 1996 in the study sites were included, and a survey on types of drinking water of these patientS was conducted. Samples of different water SOurces (well, tap, river and pond) were collected separately and microcystin concentrations were datemined by indirect competitive ELISA nlethod. Results The incidence rate of colorectal cancel was significantly higher in population who drank river and pond water than those who drank well and tap water. Compared to weU water, the relative risk (RR) for colorectal cancer was 1.88 (tap), 7.94 (river) and 7.70 (pond) respectively. The positive rate (P&50pg/mL) of microcystin in samples of well, tap, river and pond water was 0, 0, 36.23% and 17.14% respectively. Tile concentration of microcystin in river and pond water was significantly tigher than that in well and tap water (P&0.01). Spearman rank conelation analysis showed that in tile study sites, tile inicrocystin concentration of river and pond water was positively associated with the incidence of colorectal cancer (rs=0.881, P&0.01). Conclusions The types of chinking water are positively associated with the incidence of colorectal cancer in the study sites, and tiffs may be related to mcrocystin COlltanination of drinking water. Further biological study is needed to snppolt tile possible Causative role of mycrocystin in carcinogenesis of colon and rectujm.
Drinking watei，
Microcystin，
Colorectalcancer
Shu Zheng，
Kun Chert，
Xiyong Liu，
Xinyuan Ma，
Kang Chen，
Kaiyan Yao，
Lun Zhou，
* Linbo Wang，
Peiling Qiu，
Yongchuan Deng，
Suzhan Zhang
Dis Colon Rectum, January 2003，-0001，（）：
-1年11月30日
PURPOSE: Colorectal cancer is a major cause of death worldwide. To reduce the incidence and mortality from rectal cancer, an individual quantitative risk-assessment model (hereafter referred to as the Attributive Degree Value) and reverse passive hemagglutination fecal occult blood test were used in a randomized, controlled, populationbased trial that was conducted in Jiashan County, People's Republic of China. METHODS: All residents of Jiashan County aged 30 years or older were enrolled in the study, and 21 townships in the county were randomized to either a screening (n=10 townships) or control (n=11 townships) group. Participants in the screened group submitted a one-article-per-slide stool sample and completed a structured risk-assessment questionnaire from which their attributive degree value was computed. According to study protocol, 4,299 participants were defined as high risk and underwent diagnostic evaluation with 60-cm flexible sigmoidoscopy and, in some cases, an additional screening with colonoscopy. RESULTS: From 1989 to 1996, cumulative mortality from colon cancer was 90 (95 percent confidence interval, 83-97) per 100,000 in the screened group and 83 (95 percent confidence interval, 76-90) per 100,000 in the control group (log-rank 1.49, P=0.222). Mortality from rectal cancer during this time was 110 (95 percent confidence interval, 102-118) per 100,000 in the screened group, which differed significantly from the control group mortality rate of 161 (95 percent confidence interval, 152-170) per 100,000 (log-rank P=0.003). CONCLUSION: Mass screening with a reverse passive hemagglutination fecal occult blood test along with an individual attributive degree value score was effective in reducing mortality from rectal cancer but not in reducing mortality from colon cancer or the incidence of colorectal cancer.
Colorectal neoplasm，
Mass screening，
Randomized&#44，
controlled trial，
Mortality，
中华流行病学杂志，）：374～377，-0001，（）：
-1年11月30日
为了评价某一危险因素对个体发病所起的作用，并在多因素暴露情况下比较各个因素对发病的影响大小。方法
运用贝叶斯公式，依据相关流行病学理论，建立由相对危险度数值等来测算单个危险因素对个体发病贡献权重的方法。结果
建立的方法可以用来比较各个危险因素在个体发病中的贡献大小。结论
该测算方法简单方便，结合人群研究及Meta分析结果，能够为疾病的病因学研究和临床决策提供一定依据。
危险因素，
贝叶斯公式，
危险评估，
Kun Chen，
Jian Cai，
Xi-Yong Liu，
Xi-Yuan Ma，
Kai-Yan Yao，
World J Gastroenterol ):99-103，-0001，（）：
-1年11月30日
To investigate the risk factors of colon cancer and rectal cancer. METHODS: A nested case-control study was conducted in a cohort of 64 693 subjects who participated in a colorectal cancer screening program from 1989 to 1998 in Jiashan county, Zhejiang, China. 196 cases of colorectal cancer were detected from 1990 to 1998 as the case group and 980 non-colorectal cancer subjects, matched with factors of age, gender, resident location, were randomly selected from the 64 693 cohort as controls. By using univariate analysis and mutivariate conditional logistic regression analysis, the odds ratio (OR) and its 95% confidence interval (95%CI) were calculated between colorectal cancer and personal habits, dietary factors, as well as intestinal related symptoms. RESULTS: The mutivariate analysis results showed that after matched with age, sex and resident location, mucous blood stool history and mixed sources of drinking water were closely associated with colon cancer and rectal cancer, OR values for the mucous blood stool history were 3.508 (95%CI: 1.370-8.985) and 2.139 (95%CI: 1.040-4.402) for the mixed drinking water sources, 2.387 (95%CI: 1.243-4.587) and 1.951 (95 %CI: 1.086-3.506) respectively. All reached the significant level with a P-value less than 0.05. CONCLUSION: The study suggested that mucous blood stool history and mixed sources of drinking water were the risk factors of colon cancer and rectal cancer. There was no any significant association between dietary habits and the incidence of colorectal cancer.
中华流行病学杂志，）：487～491，-0001，（）：
-1年11月30日
研究海岛地区居民膳食营养素摄入量与胃癌发病的关系。方法
采用频数匹配的病例对照研究方法，随机选择舟山市原发性胃癌新发病例103例和健康人群对照133名，进行有关饮食因素的调查，并把各饮食项目折算成16种营养素的日均摄入量后以非条件logistic回归法分析其与胃癌发生的关系。结果
在调整了非饮食因素和总热能对各项营养素的干扰后，蛋白质（ORQ4. Q1=10.3；趋势检验的P=0.01)、饱和脂肪酸（ORQ4 Vs. Q1=3.24）、胆固醇（ORQ4 vs.Q1=2.76）等在男性组为胃癌的危险因素，无论男、女性组钠的摄入量均为病例组高于对照组；而维生素
A、C在女性组均为胃癌的保护因素。结论
高蛋白质、饱和脂肪酸、胆固醇、盐及低维生素A、c饮食可能是胃癌的危险因素。
病例对照研究
Li-Ming Sui，
Kun Chcn，
Pai-An Hwang，
Dcng-Fwu Hwang *
，-0001，（）：
-1年11月30日
Study objective: To asses the association between alcohol consumption and the risk of colo-rectal cancer (CRC) in the Chinese population. De-sign: A population-based prospective cohort study was initiated from the colorectal cancer screening population in
LI MING SHUI，
KUN CHEN，
JIAN YUE WANG，
HONG ZHOU MEI，
AI ZENG WANG，
YA-HUI LU，
AND DENG-FWU HWANG，
J. Food Prot., Vol. 66, No.1，-0001，（）：
-1年11月30日
Outbreaks of paralytic snail poisoning have recently occurred in Asia, especially in China. The epidemiological charac-teristics of this disease from an outbreak in Zhoushan City, China, were recorded. Forty-two outbreaks of paralytic snail poisoning, involving 309 cases of illness, occurred from 1977 to 2001. Sixteen people (5.2%) died, 48 people (15.5%) required intubations, and 140 people (45.3%) required emergency hospital treatment as a result of these outbreaks. Outbreaks involved
multiple marine snail species and occurred primarily during the summer (from June to August) on 11 islands with high population densities. Peak numbers of outbreaks and amounts of snail toxicity occurred from 1978 to 1979, from 1985 to 1987, and from 1992 to 1994. Toxicity varied depending on specimen, region, and season. The toxin involved was identified as tetrodotoxin. The data obtained in this study suggest that snails should not be eaten unless they are certified to be nontoxic.
中华消化杂志，）：377～379，-0001，（）：
-1年11月30日
结直肠癌是常见消化道恶性肿瘤之一，谷胱甘肽转移酶（glutathione S-thransferases，GST）是体内重要的Ⅱ相解毒酶家系，参与如多环芳烃、杂环胺等致癌物质的解毒过程，GsT Mu（GsTMl）和GsT Theta（GSTTl）基因缺失会导致相应酶活性的降低[1]。本研究对象来自浙江省嘉善县，采用以人群为基础的结直肠癌随访队列，进行GSTMl和GsTTl基因多态性、饮食与结直肠癌易感性的病例对照研究。
Kun Chen，
Qinting Jiang，
Xinyuan Ma，
Qilong Li，
Kaiyan Yao，
Weiping Yu & Shu Zheng
Accepted in revised form 6 September 2004，-0001，（）：
-1年11月30日
Study objective: To asses the association between alcohol consumption and the risk of colo-rectal cancer (CRC) in the Chinese population. De-sign: A population-based prospective cohort study was initiated from the colorectal cancer screening population in Jiashan County in . The
drinking habits of individuals were investigated with demographic information S A cohort study
was followed-up from 1st Mav 1990 to lst January 2001 and censored at the date of diagnosis of CRC, at death from any causes. or at 1st January 2001. whichever came first. and the person-time was com-
puted Participants: Two hundred and forty two CRC patients were diagnosed during the study period and
64, 100individuals finished the follow-up Results: The distribution of sex, smoking status, occupation, edu-cation 1evel and marital status were a11 significantly different among difierent drinking habits at baseline When the above factors were adjusted, no significant association was observed between alcohol consump-tion and the risk of CRC. Exclusion of individuals diagnosed cancer less than 1 year after the examina-tion date did not alter the strength of an alcoh01 CRC relationship Further analysis in sex strata also did not show a significant relationship Conclusions Alcoh01 drinking may not be associated with a higher risk of CRC in the Chinese population.
Alcohol drinking，
Cohort study，
Colorectal cancer，
Prospective study
中国环境科学，）：41～44，-0001，（）：
-1年11月30日
为探讨乳腺癌发病与有机氯农药污染的关系，采片分阶段整群随机抽样的方法，按乳腺癌标化发病率高低抽取11个乡镇，再随机抽取行政村、自然村，测定再乡镇大米和土壤样品中有机氯各指标的含量，结台各乡镇的乳腺癌发病资料，进行统计分析结果表明，各乡镇的乳腺癌标化发病率存在统计学显著性差异；大米中&-HcH、y-HcH、五氯酚钠以及土壤的&-HcH含量在各乡镇间有显著性差异；乳腺癌标化发病率与大米中PP'-DDD含量呈负相关，相关系数为-0.609，说明经过近20年的降解过程，DDT的衍生物含量最终以PP'-DDD居多，并且乳腺癌标化发痛率与大米中PP'-DDD含量呈负相关。}