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复旦大学 硕士学位论文
聚天冬氨酸及其衍生物的制备、表征和应用 姓名：陈伟 申请学位级别：硕士 专业：高分子化学与物理 指导教师：汪长春 座机电话号码 摘要 硕士毕业论文 聚天冬氨酸及其衍生物的制备、表征及其应用 研究生：陈伟导师汪长春教授 ． 复旦大学高分子系 摘要 聚天冬氨酸及其衍生物因其自身良好的生物相容性和生物降解性，在生物医 学领域有着广阔的应用前景。国内外已经对聚天冬氨酸的嵌段共聚物做了大量的 研究。通过接枝方法来制备聚天冬氨酸衍生物可以有效的控制聚天冬氨酸的结 构，并实现对其亲疏水性的调节。本论文工作的主要目的是通过简单的合成和改
性，制备出生物相容性好的聚天冬氨酸及其衍生物，并对制备的聚合物进行初步
应用。研究工作主要包括以下几个部分： 通过化学共沉淀法制备聚天冬氨酸稳定的磁流体，通过FTIR，TGA证实聚
天冬氨酸中羧基与四氧化三铁纳米粒子的化学偶联作用，并用TEM，Ⅺ①和
VSM研究了磁流体的相关性质，最后通过比较柠檬酸钠稳定磁流体和聚天冬氨
酸稳定磁流体的细胞毒性来表明聚天冬氨酸具有良好的生物相容性和低毒性。 成功制备了聚乙二醇接枝的聚天冬氨酸 PEG―g-PAsp 。一方面，研究了它与
十六烷基三甲基溴化铵自组装形成聚离子胶束的情况，并研究了该体系的各种性
质。另一方面，通过其与抗肿瘤药物阿霉素的化学缩合制备得到高分子药物聚乙
二酵接枝的聚天冬氨酸 阿霉素 ，将该高分子药物进行相关的小鼠毒性实验和
抗肿瘤实验，表明聚合物接枝阿霉素后大大减小了药物毒性但一定程度上降低了
药物的抗肿瘤活性。 制备了两种聚天冬氨酸的衍生物：聚乙二醇接枝聚天冬氨酸 P
正在加载中，请稍后...Fuqian Yang
| Materials Engineering&&&&&&&&&&&&&&&&&&&
Publications
PUBLICATIONS IN REFEREED, ARCHIVAL JOURNALS
Papers accepted for publication
, Nanoindentation of carbon microspheres,
International Journal of Materials Research
3. Yuan Sun, Rong Chen, Stephen M Lipka, and Fuqian Yang, Current-induced strength degradation of activated carbon spheres in carbon supercapacitors, Materials Research Express
4. Yong Li, Kai Zhang, Bailin Zheng, and Fuqian Yang, Effect of local deformation on the coupling between diffusion and stress in lithium-ion battery, International Journal of Solids and Structures
5. Huihui Nie, Wei Liang, Fuqian Yang, Liuwei Zheng, Xianrong Li, and Haiwei Fan, Texture evolution of single-pass hot rolled 5052/AZ31/5052 clad sheets, JOM
6. Fuqian Yang, A nonlinear viscous model for Sn-whisker growth, Metallurgical and Materials Transactions A
7. J.S. Peng, Fuqian Yang, Donyau Chiang, and Sanboh Lee, Kinetics of field-induced surface patterns on PMMA, Langmuir
8. Francesca Condemi, Dongfang Wang, Gionata Fragomeni, Fuqian Yang, Guangfeng Zhao, Cameron Jones, Cherry Ballard-Croft, and Joseph B. Zwischenberger, Percutaneous double lumen cannula for right ventricle assist device system: A computational fluid dynamics study, Biocybernetics and Biomedical Engineering
9. Wanggang Zhang, Yiming Liu, Diaoyu Zhou, Jing Wen, Liuwei Zheng, Wei Liang, and Fuqian Yang, Diffusion kinetics of gold in TiO2 nanotube arrays for formation of Au@TiO2 nanotube arrays, RSC Advances
1. Fuqian Yang and Ya-Pu Zhao, Effect of a capillary bridge on the crack
opening of a penny crack, Soft Matter 12 ( - 1592
2. Shaofeng Yin, Ziming Zhao, Weiling Luan, Fuqian Yang, Optical response of quantum dots-epoxy resin composite: effect of tensile strain, RSC Advances 6 (-18133
4. Mimi X. Yang and Fuqian Yang, Electric analysis of a conducting hemisphere, Journal of Physics D: Applied Physics 49 ( (6pp)
5. Yong Li, Kai Zhang, Bailin Zheng, and Fuqian Yang, Effect of local velocity on diffusion-induced stress in large-deformation electrodes of lithium-ion batteries, Journal of Power Sources 319 (7
, Langmuir 31 (-4031
Yu-Hsiang Chen, Yunfei Jia, Fuqian Yang, Chien-Chao
Huang, and Sanboh Lee, Boussinesq problem of a Burgers viscoelastic layer on an
elastic substrate, Mechanics of Materials
11. Fuqian
Yang, Field-limited migration of Li-ions in Li-ion battery, ECS Electrochemistry Letters 4 (2015) A7-A9
15. , 95 (-3496
16. , 647 (0
Fuqian Yang, Entropy change-induced elastic
softening of lithiated materials, Theoretical
and Applied Mechanics Letters 5 (7
118 (&26865
2. Fuqian Yang, A simple model for
diffusion-induced dislocations during the lithiation of crystalline materials, Theoretical & Applied Mechanics Letters 4
Wang, Feng-Chao Wang, Fuqian Yang, and Hengan Wu, Molecular kinetic theory of boundary
slip on textured surfaces by molecular dynamics simulations, Science China: Physics, Mechanics &
Astronomy 57
4. Fuqian Yang, Comments on &Effects of dislocation mechanics on diffusion-induced stresses within a spherical insertion particle electrode&, Journal of Materials Chemistry A 2 (-17184
5. Donyau Chiang, Fuqian Yang, Chi Wei Liu, Kuo-Chen
Ho, and Sanboh Lee, Methanol desorption in Poly(Methyl Methacrylate), Journal of Materials Research 29
Sun and Fuqian Yang, Formation of well-ordered finger-like structures on
pre-cast thin films, RSC Advances 4 (2014)
45535 - 45539
Sun and Fuqian Yang, Formation of self-organized
gradient stripes on pre-cast poly(methyl methacrylate) films, Langmuir 30 (-655
Sun and Fuqian Yang, Evaporation-induced formation of self-organized gradient
concentric rings on sub-micron pre-cast PMMA films, Soft Matter 10 (-4457
Sun and Fuqian Yang, Self-organization of unconventional gradient concentric
rings on pre-cast PMMA films, Journal of
Physical Chemistry C 118 (&10182
10. Yuan Sun, Guangfeng Zhao, Xiyu Wen, Junwei Qiao,
Fuqian Yang, Nanoindentation deformation of a bi-phase AlCrCuFeNi2 alloy, Journal of Alloys and Compounds 608 (
11. Meng-Lin Lin, Fuqian Yang, J.S. Peng, and Sanboh
Lee, Field effect on digestive ripening of thiol-capped gold nanoparticles, Journal of Applied Physics 115(2014)
12. Yunfei Jia, Fu-Zhen Xuan, Xiaoping Chen, and Fuqian Yang, Finite element analysis of cyclic indentation of bi-layer enamel, Journal of Physics D: Applied Physics 47(
13. Ming Liu and Fuqian Yang, Indentation-induced interface decohesion between a piezoelectric film and an elastic substrate, Journal of Computational and Theoretical Nanoscience 11(-1873
14. Meng-Lin
Lin, Fuqian Yang, and Sanboh Lee, Digestive ripening of thiol-capped gold
nanoparticles: the effects of adding dodecanethiol and reflux heating, Colloids and Surfaces A: Physicochemical and
Engineering Aspects 448 (
15. Yunfei
Jia, Fu-Zhen Xuan, and Fuqian Yang, Finite
element analysis of depth effect on measuring elastic modulus of a core-shell
structure for application of instrumented indentation in tooth enamel, Materials
Science and Engineering C 37C(
16. Guangfeng Zhao and Fuqian Yang, Effect of DC current on tensile creep of pure tin, Materials Science & Engineering A
17. Yueh-Ying Lee, Fuqian Yang, C.C. Chen and Sanboh Lee, Process comparison for fracture-induced formation of surface structures on polymer films, Thin Solid Films
18. Fuqian Yang and Ming Liu, Analysis for the indentation with a flat indenter on an elastic-perfectly plastic thin film, Journal of Computational and Theoretical Nanoscience 11 (1
19. Paul Ayayee, Fuqian Yang, and Lynne Rieske-Kinney, Biomechanical properties of hemlocks: A novel
approach to evaluating physical barriers of the plant-insect interface and
resistance to a phloem-feeding herbivore, Insects 5(6
20. Yuan Sun, Guangfeng Zhao, and Fuqian Yang, Anisotropic behavior of the nanoindentation of single carbon fibers, Nanoscience and Nanotechnology Letters
21. Fuqian Yang, Effect of electric
current on trijunction equilibrium and grain rotation of lossy dielectrics, Journal of Electronic Materials 43 (-4501
1. Fuqian Yang, Boussinesq contact of transversely isotropic piezoelectric materials, International Journal of Applied Electromagnetics and Mechanics
Fuqian Yang, Effect of the interlayer deformation on the blister test, Journal of Adhesion Science and Technology
3. Fuqian Yang and J.C.M. Li, Impression test & a review, Materials Science and
Engineering R 74 (3
4. J.W. Qiao, T. Zhang, F.Q. Yang, P.K. Liaw, S. Pauly, and
B.S. Xu, A tensile deformation model for in-situ metallic glass matrix
composites, Nature Scientific Reports 3 (
5. Jianfeng Zhang, Fu-Zhen
Xuan, and Fuqian Yang, Effect of
subsurface damage on the characteristics of nonlinear Rayleigh wave in glass,
Journal of Non-Crystalline Solids 378 (5
6. Fuqian Yang, Effect of diffusion-induced bending on diffusion-induced stress near
the end faces of an elastic hollow cylinder, Mechanics Research Communications 51 (
7. Guangfeng Zhao, Ming Liu,
Zhinan An, Yang Ren, Peter K. Liaw, and Fuqian Yang, Electromechanical
responses of Cu strips, Journal of
Applied Physics 113 (
Yang, Insertion-induced expansion of a thin film on a rigid substrate, Journal of Power Sources 241 (9
Jia, Fu-Zhen Xuan, and Fuqian Yang, Analysis of the effect of a compliant layer
on the indentation of an elastic material, Journal
of the Mechanical Behavior of Biomedical Materials 25 ()
10. Changzeng Luo, Wei Liang, Zhiqiang Chen, Jianjun Zhang, Chengzhong Chi, and Fuqian Yang, Effect of high temperature annealing and subsequent hot rolling on microstructural evolution at the bond-interface of Al/Mg/Al alloy laminated composites, Materials Characterization 84 (
11. Ming Liu and Fuqian Yang,
Orientation effect on the Boussinesq indentation of a transversely isotropic
piezoelectric material, International
Journal of Solids and Structures 50 (&2547
12. Ming Liu and Fuqian Yang,
Three dimensional finite element simulation of the Berkovich indentation of a
transversely isotropic piezoelectric material: effect of material orientation, Modelling and Simulation in Materials
Science and Engineering 21(
13. Jianfeng Zhang, Fu-Zhen
Xuan, Yanxun Xiang, and Fuqian Yang, Nonlinear ultrasonic response of
plastically deformed aluminum alloy AA 7009, Materials Science and Technology 29 (-1309
14. W.C. Liu, M. Ma, and Fuqian
Yang, Effect of the heat-treatment on the cube recrystallization texture of
Al-Mn-Mg aluminum alloy, Metallurgical
and Materials Transactions A 44A (-2868
15. Chiao-Chi Lin, Fuqian Yang,
Joannie W. Chin, Lipiin Sung, and Sanboh Lee, Stress-assisted formation of
surface gratings on polymer films, Polymer
Engineering and Science 53(-1462
16. M.H. Li, M. Ma, W.C. Liu,
Fuqian Yang, Recrystallization behavior of cold-rolled Zr 702, Journal of Nuclear Materials 433(2013)
Ming Liu and Fuqian Yang,
Effect of electric boundary conditions on the spherical indentation of
transversely isotropic piezoelectric films, Smart
Materials and Structures 21 (
2. Guangfeng Zhao and Fuqian
Yang, Effect of alternating electric current on the nanoindentation of copper, Applied Physics A 109(9
3. Ming Liu and Fuqian Yang,
Finite element analysis of the spherical indentation of transversely isotropic
piezoelectric materials, Modeling and Simulation in Materials Science and Engineering 20 (
4. Fuqian Yang and Linan An,
Eelectrothermal stress in conducting particulate composites, Journal of Materials Science 47(-6236
5. Pei-Yu Liang, Fuqian Yang,
and Sanboh Lee, Fracture-induced formation of semi-concentric patterns on polymeric
films, Materials Chemistry and Physics
6. Qingliu Wu, Juchuan Li,
Rutooj Deshpande, Navaladian Subramanian, Stephen Rankin, Fuqian Yang, and
Yang-Tse Cheng, Aligned TiO2 nanotube arrays as durable lithium-ion
battery negative electrodes, Journal of
Physical Chemistry C 116(-19677
7. Juchuan Li, Xingcheng Xiao,
Fuqian Yang, Mark W Verbrugge, Yang-Tse Cheng, Potentiostatic intermittent
titration technique (PITT) for spherical particles with finite interfacial
Electrochimica Acta 75(
8. Guangfeng Zhao, Ming Liu,
and Fuqian Yang,
effect of an electric current
on the nanoindentation behavior of
tin, Acta Materialia 60(-3782
9. Fuqian Yang, Diffusion-induced
stress in inhomogeneous materials: concentration-dependent elastic modulus,
Science China: Physics, Mechanics and Astronomy 55(2
10. Fuqian Yang, Effect of
surface viscosity on the vibration of microcantilevers, Langmuir 28(-2452
11. Juchuan Li, Xingcheng Xiao,
Fuqian Yang, Mark Verbrugge, and Yang-Tse Cheng, Potentiostatic intermittent
titration technique (PITT) for electrodes governed by diffusion and interfacial
reaction, Journal of Physical Chemistry C 116(&1478
12. Ming Liu and Fuqian Yang, Finite
element analysis of the indentation-induced delamination of bi-layer structures, Journal of Computational and Theoretical
Nanoscience &9(8
13. Ming Liu and Fuqian Yang, Finite
element analysis of current-induced thermal stress in a conducting sphere, Journal of Electronic Materials 41(2012)
14. W. H. Jiang, F. Jiang, F. X.
Liu, Y. D. Wang, H. M. Dang, F. Q. Yang, H. Choo, and P. K. Liaw, Mechanical
behaviours of workhardening and worksoftening bulk metallic glasses, Materials Science and Technology 28(2012)
15. Gang Shao, Guangfeng Zhao, Chengying Xu, Fuqian
Yang and Linan An, Ceramic nanocomposites reinforced with a high volume
fraction of carbon nanofibers, Materials
Letters 68 (1
Shan-Shan Shao, Fuqian
Yang, and Fu-Zhen Xuan, Effect of electromigration on diffusional creep in
polycrystalline materials, International
Journal of Applied& Electromagnetics and
Mechanics 40(1
Ming Liu and Fuqian Yang, Effect of crystal
orientation on piezoelectric response of single-crystal piezoelectric layers,
Journal of Computational and Theoretical Nanoscience 9(-2067
Jing Cheng, Fuqian Yang,
Paul T. Vianco, Bei Zhang, James C.M. Li, Optimum thickness of Sn film for whisker
growth, Journal of Electronic Materials 40(2011)
2. Juchuan Li, Alan K. Dozier, Yunchao Li, Fuqian Yang, Yang-Tse Cheng, Crack pattern formation in thin film lithium-ion battery electrodes, Journal of The Electrochemical Society 158(2011) A689-A694
Ning Zhang, Fuqian Yang, Yaowu Shi, Fu Guo, Compression creep of 63Sn37Pb solder balls, Acta Materialia 59( -3163
Feng-Chao Wang, Fuqian Yang, and Ya-Pu Zhao, Size effect on the coalescence-induced self-propelled droplet, Applied Physics Letters 98(
5. Fuqian Yang (Invited), Adhesive contact between a rigid axisymmetric indenter and a neo-Hookean solid, Journal of Adhesion
6. Rong Chen and Fuqian Yang, Effect of electric current on the creep deformation of lead, Materials Science and Engineering A
7. Juchuan Li, Fuqian Yang, Yang-Tse Cheng, Jia Ye, Whisker formation on tin anode of lithium-ion battery, Journal of Power Sources
8. Fuqian Yang, Criterion for insertion-induced microcracking and debonding of thin films, Journal of Power Sources 196(9
9. Amir K. Miri, Reza Avazmohammadi, and Fuqian Yang, Effect of surface stress on the deformation of an elastic half-plane containing a nano-cylindrical hole under a surface loading, Journal of Computational and Theoretical Nanoscience 8(6
1. S. N.V.R.K. Kurapati, Y. C. Lu, and Fuqian Yang, Indentation load-displacement relations for the spherical indentation of elastic film/substrate structures, CMC: Computers, Materials, & Continua 20(
2. Fuqian Yang and Guangfeng Zhao (Invited), Effect of electric current on nanoindentation of copper, Nanoscience and Nanotechnology Letters 2(6
3. Rong Chen and Fuqian Yang, Effect of DC current on the creep deformation of tin, Journal of Electronic Materials
4. Ning Zhang, Yaowu Shi, Fu Guo, and Fuqian Yang, Study of the impact performance of solder joints by high-velocity impact tests, Journal of Electronic Materials 39(-2543
5. J. W. Qiao, Fuqian Yang, G. Y. Wang, P. K. Liaw, and Y. Zhang, Jerky-flow characteristics for a Zr-based bulk metallic glass, Scripta Materialia 63(-1084
6. Fuqian Yang, Insertion-induced breakage of materials, Journal of Applied Physics 108 (
7. Rong Chen, Fuqian Yang, and Y. Charles Lu, Impression creep of lightweight alloys, SAE International Journal of Materials and Manufacturing 3(4
8. Fuqian Yang, Effect of local solid reaction on diffusion-induced stress, Journal of Applied Physics 107(
9. Fuqian Yang, Size effect on the effective bulk modulus of nanocomposites with core-shell nanospherical inclusions, Materials Science and Engineering A 527 (&3917
10. Fuqian Yang and Ding Li, Indentation-induced formation of low-dimensional Si-structures in KOH solution, Journal of Physics D: Applied Physics 43 (
11. Ding Li, Mimi Yang, Fuqian Yang, and Peter K. Liaw, Stress-assisted-electrochemical corrosion of Cu-based bulk metallic glass, Journal of Materials Research 25(7
12. Ding Li, and Fuqian Yang, Anelastic indentation recovery of bioglass 45S5 at room temperature, Journal of Non-Crystalline Solids 356(1
13. Fuqian Yang and Linan An, Stress analysis of the field-assisted sintering: electrothermal mechanical interaction, International Journal of Applied Electromagnetics and Mechanics 32(2
14. Fuqian Yang, Slip boundary condition for viscous flow over solid surface & A rate process, Chemical Engineering Communication 197(0
15. Rong Chen, Y.C. Lu, Fuqian Yang, G.P. Tandon, G.A. Schoeppner, Impression creep of PMR-15 resin at evaluated temperatures, Polymer Engineering & Science 50(3
1. Fuqian Yang, Current-induced thermal stresses in a metal cylinder, Journal of Applied Physics 106(. Also in January 4, 2010 issue of Virtual Journal of Nanoscale Science & Technology
2. Yen-Chang Tseng, Youling L. Xiong, and Fuqian Yang, Influence of inulin/oligofructose on the acid-induced cold aggregation and gelation of preheated soy proteins, Journal of the Science of Food and Agriculture 89(&2658
3. Fuqian Yang, Effect of surface energy on tensile deformation of nanotubes, Journal of Physics D: Applied Physics 42(
4. Yang-Tse Cheng and Fuqian Yang, Obtaining Shear Relaxation Modulus and Creep Compliance of Linear Viscoelastic Materials from Instrumented Indentation using Axisymmetric Indenters of Power-law Profiles, Journal of Materials Research 24(-3017
5. Fengxiao Liu, Fuqian Yang, Yanfei Gao, Wenhui Jiang, YinFeng Guan, Philip D. Rack, O. Sergic, Peter K. Liaw, Micro-scratch study of a magnetron sputtered Zr-based metallic-glass film, Surface & Coatings Technology 203(-3484
6. John A. Nychka, Sherri L.R. Mazur, Satadru Kashyap, Ding Li, and Fuqian Yang, Dissolution of Bioactive Glasses: The Effects of Crystallinity Coupled with Stress, JOM 61(
7. Ding Li, Mimi Yang, Pavitra Muralidhar, Connie Wu, and Fuqian Yang, Local surface damage and material dissolution in 45S5 bioactive glass: Effect of the contact deformation, Journal of Non-Crystalline Solids 355(9
8. Fuqian Yang, Hongmei, Dang, Gongyao Wang, Yoshihiko Yokoyama, Peter K. Liaw, Indentation behavior of ZCAP-3 bulk metallic glass: effects of the fatigue deformation, Journal of Materials Research &24(-2352
9. Reza Avazmohammadi, Fuqian Yang, Saeed Abbasion, Effect of interface stresses on the elastic deformation of an elastic half-plane containing an elastic inclusion, International Journal of Solids and Structures 46(&2906
10. Fuqian Yang, Yang-Tse Cheng, Revisit of the indentation deformation of an elastic half-plane, Journal of Materials Research 24(-1982
11. Fuqian Yang and Hongmei Dang, Effect of electric field on the nanoindentation of Zinc Sulfide, Journal of Applied Physics 105(
12. Fuqian Yang, Ding Li, Mimi L. Yang, Ran Li, Wenhui Jiang, Gongyao Wang, Tao Zhang, Peter K. Liaw, Localized deformation of a Cu46.25Zr45.25Al7.5Er1 bulk metallic glass, Journal of Physics D: Applied Physics 42 (}