Electropolymers for (nano-)imprinted biomimetic biosensors - ScienceDirect
ExportChapter contentsBook contentsJavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page.Sensing with Nanotubes, Nanowires and Nanoparticles2014, Pages 125-149Author links open overlay panelShow moreAbstract:Synthetic functional and cross-linking monomers may be electropolymerised in the presence of the target analyte to create polymers that mimic the active sites of biopolymers, e.g. antibodies, enzymes or nucleic acids. In a biomimetic sensor the molecularly imprinted polymer (MIP) must be in close proximity to the surface of the signal-generating electrode. By using electropolymerisation, thin MIP films can be obtained directly on the surface of the transducer. Integration of nanomaterials into the sensing layer has several advantages, such as increase of the surface area, mass transport and conductivity. These materials also provide a foundation for the electrochemical preparation of catalytically active MIPs.Key wordsmolecularly imprinted polymer (MIP)electropolymerisationbiomimetic sensorsnanomaterialsenzyme mimicsChoose an option to locate/access this article:Check if you have access through your login credentials or your institution.ororRecommended articlesCiting articles (0)Disposable Bioreactors - ScienceDirect
ExportJavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page., 2011, Pages 249-261Author links open overlay panelShow moreAbstractSingle-use bioreactors (SUBs) show clear benefits compared to the traditional fixed glass and steel bioreactor equipment used for bioprocessing. Reduction of validation efforts, sterilization in advance, and ease of use have a positive impact on costs and timelines for the development of biopharmaceuticals. Several types of SUBs have been introduced, where rocking-type systems and tank liners are predominantly used. Rocking-type bioreactors are restricted in their use up to 100 l working volumes, whereas the stirred SUBs can be applied in a range from 50 to 2000 l. The rocking-type bioreactors are restricted in use to mammalian cell cultures. To date, stirred-type SUBs have only been applied for mammalian cell culture as well. In both Chinese hamster ovary (CHO) and PER.C6(R) cultures, these bioreactors result in process performance comparable to the traditional glass or steel bioreactors, and are applied with high-intensity cell-culture processes (XD(R) process) as well. A new type of rocking bioreactor, the CELL-tainer(R), is capable of generating high mass-transfer coefficients and opens up the potential of application of SUBs in high-intensity cell cultures as well as in microbial cultures.KeywordsBioprocessingCell culture processCELL-tainer(R) bioreactorCHO cellsSingle-use bioreactorOxygen mass transferPER.C6(R) cellsScale-upSingle-use sensorsChoose an option to locate/access this article:Check if you have access through your login credentials or your institution.ororRecommended articlesCiting articles (0)Nico Oosterhuis has received his MSc as bioprocess engineer from Wageningen University and received PhD from Delft University (1984) with a thesis on ‘Scale-up of bioreactors’. He worked for more than 20 years for various companies (including fermentation equipment, food- and agricultural processing industry, and the biopharmaceutical industry). At DSM Biologics, he was responsible for the PER.C6(R) development project. Nico started in 2005, CELLution Biotech BV, involved in the development of innovative concepts for single-use bioreactors. For some years, Nico was visiting professor at the Aalborg University in Denmark (bioprocess design and scale-up). Nico has contributed to several publications and patents. At present, he is CTO/CSO at CELLution Biotech BV, and acts besides as senior consultant in the field of bioprocessing for the agro- and food industry.Terry Hudson received his PhD from the University of Texas at Austin. After completing his doctorate, he worked for 4 years at Merck & Co., Inc (Elkton, VA, USA) in technical operations and manufacturing positions focused on upstream and downstream manufacturing of multiple fermentation-based therapeutics. In 2006, Terry joined Genentech (Oceanside, CA, USA) as the Process Research and Development (PR&D) pilot plant manager. Currently, he is a PR&D Group Lead, managing a cross-functional team (cell culture, purification, analytical, and formulation) and the cell culture functional lead with responsibility for the process development of early-stage therapeutics and technology development.Alberto D’Avino received his PhD from the University of Naples (Italy) with a thesis on production of molecules of biotechnological interest from lactic acid bacteria. Following his PhD, Alberto joined DSM Biologics (Groningen, The Netherlands) in 2008. Currently, he is scientist in the R&D department with responsibility for process development, technology transfer, and technology development of cell culture-based processes.Gerben Zijlstra received his PhD from Wageningen University (The Netherlands) with a thesis on process integration in the field of animal cell culture. Following his PhD, Gerben joined DSM Biologics in 1994, where he held various positions with responsibility for process development, cGMP manufacture, process equipment and facility engineering projects, and technology transfer of cell culture processes. Gerben is presently senior scientist in the R&D department with responsibility for the process development of early-stage therapeutics and technology development, including introduction of disposable technologies and cell culture process intensification.Ashraf Amanullah received his PhD from the University of Birmingham (UK). Following his PhD, he worked on several industrially sponsored postdoctoral projects, including those with Novo Nordisk (Denmark), and Merck (USA). He held various positions at Merck & Co. Inc. (West Point) with responsibility for process development, cGMP manufacture, and technology transfer of cell culture and fermentation-based vaccine processes. Ashraf joined Genentech Inc. in 2006 after 9 years at Merck Research Labs. Currently, he is associate director at Genentech (Oceanside, CA, USA), where he heads a cross-functional department (cell culture, purification, analytical, and formulation) with responsibility for the process development of early-stage therapeutics and technology development.香港（中国）：+852-
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ExportChapter contentsBook contentsJavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page.2013, Pages 7-39Author links open overlay panelShow moreChoose an option to locate/access this article:Check if you have access through your login credentials or your institution.ororRecommended articlesCiting articles (0)Novel and self-healing anticorrosion coatings using rare earth compounds - ScienceDirect
ExportChapter contentsBook contentsJavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page.Woodhead Publishing Series in Metals and Surface Engineering2014, Pages 233-266Author links open overlay panelShow moreAbstract:Self-healing materials have the ability to repair themselves and recover functionality after degradation, damage and failure. This chapter reviews recent developments in self-healing protective coatings which contain rare earth-based inhibiting compounds for active corrosion protection of metals. These new ‘green’ inhibitors are being developed as substitutes for chromate-based inhibitors. Different types of organic, hybrid and metallic systems are considered, with particular emphasis on thin sol-gel based layers. The main strategies for encapsulation of RE inhibitors are also reviewed. Significant future effort is required to improve the properties of organic coatings and to explore new self-healing coating alternatives that allow controlled release of the inhibitor.Key wordsself-healing coatingactive corrosion protectionsol-gel coatingencapsulationChoose an option to locate/access this article:Check if you have access through your login credentials or your institution.ororRecommended articlesCiting articles (0)}