Paris polyphylla Suppresses Proliferation and Vasculogenic Mimicry of Human Osteosarcoma Cells... - Abstract - Europe PMC
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+ Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu Province, P.R. China.
? Department of Orthopaedics, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu Province, P.R. China.
Yimin Wang
§ Department of Orthopedics, The Third Affiliated Hospital of Soochow University, (The First People's Hospital of Changzhou), Changzhou City 213003, Jiangsu Province P.R. China.
Qiaomei Jin
+ Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu Province, P.R. China.
? Nanjing Biopharmaceutical Innovation Platform Company Limited, Nanjing 210032, Jiangsu Province, P.R. China.
+ Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu Province, P.R. China.
Cuihua Jiang
+ Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu Province, P.R. China.
Dongjian Zhang
+ Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu Province, P.R. China.
? Department of Orthopaedics, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu Province, P.R. China.
? Department of Orthopaedics, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu Province, P.R. China.
+ Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu Province, P.R. China.
∥ Jinling Hospital, Department of Orthopedics, Nanjing University, School of Medicine, Nanjing 210002, Jiangsu Province, P.R. China.
Jian Zhang
+ Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu Province, P.R. China.
+ Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu Province, P.R. China.
? Department of Orthopaedics, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu Province, P.R. China.
§ Department of Orthopedics, The Third Affiliated Hospital of Soochow University, (The First People's Hospital of Changzhou), Changzhou City 213003, Jiangsu Province P.R. China.
? Nanjing Biopharmaceutical Innovation Platform Company Limited, Nanjing 210032, Jiangsu Province, P.R. China.
∥ Jinling Hospital, Department of Orthopedics, Nanjing University, School of Medicine, Nanjing 210002, Jiangsu Province, P.R. China.
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[06 Apr ):575-598]
Journal Article
Paris polyphylla, a traditional antipyretic-detoxicate chinese medicinal herb, has been applied extensively in cancer treatments for nearly 2000 years. The purpose of the present study is to evaluate the potential anti-osteosarcoma effects of Paris polyphylla ethanol extract (PPEE) and to investigate its underlying mechanisms. The antiproliferation activity of PPEE was tested on 143B, MG-63, U-2 OS and hFOB1.19 cells using MTT assay. The pro-apoptotic and cell cycle arrest effects of PPEE were confirmed by Hoechst 33342 staining and flow cytometry. The antimigratory, anti-invasive and antivasculogenic mimicry (VM) effects of PPEE were investigated by wound healing, Transwell and 3D culture assays. Mouse xenograft model was used to examine its anti-osteosarcoma efficacy in vivo. Hematologic profiles and hepatorenal functions were evaluated to assess the toxicity of PPEE.&PPEE evidently suppressed cell proliferation of 143B, MG-63 and U-2 OS with IC50 values of 10-60[Formula: see text][Formula: see text]g/mL, but showed little cytotoxicity against normal osteoblastic cell. PPEE promoted apoptosis in 143B cell via caspase activation, increased Bax/Bcl-2 ratio and PARP cleavage. It also induced G2/M phase arrest associated with elevated phosphorylation of CDK1, Cdc25C, Chk2 and down-regulation of cyclin B1, CDK1, Cdc25C expression. Additionally, PPEE inhibited 143B cell migration, invasion and VM formation at noncytotoxic concentrations through decreasing the expression of FAK, Mig-7, MMP2 and MMP9. Finally, daily oral administration of PPEE for four weeks exhibits potent antitumor and anti-VM activity in 143B xenograft model with low toxicity. Taken together, these findings demonstrated PPEE possesses anti-osteosarcoma and anti-VM activity in vitro and in vivo, and therefore is a potential candidate for osteosarcoma treatment.
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Morningstar正在初始化报价器艾蒿种子怎么培育？那女子刀毖艾草的适应性强，普遍生长于路旁荒野、草地。只要是向阳而排水顺畅的地方都生长，但以湿润肥沃的土壤生长较好。
艾草种植要求日照充足通风良好，排水良好的沙质壤土为佳，有利生长。种子直播，每穴3-5粒，株高5CM时须疏苗，以利生长。株高30CM时可撒肥料，让叶子及茎干充分生长，因特殊叶形及特殊需要银色色彩，近年来常被花艺老师拿来作花材。艾草很容易种的，多施肥，长的特快的。
更多回答香蒲75您好，很乐意为您解决这个问题，一、生产中主要以根茎分株进行无性繁殖，需要注意分株的时间。但也可用种子繁殖。一般进行种子繁殖在3月份播种，根茎繁殖在11月份进行。[2]二、选址需谨慎。畦宽1.5米左右，畦面中间高两边低似“鱼背”型，以免积水，造成病害。三、施肥有讲究。播种前要施足底肥，一般每667米2施腐熟的农家肥4000千克，深耕与土壤充分拦匀，排后即浇一次充足的底水。三、肥料有要求。每年3月初在地越冬的根茎开始萌发，4月下旬采收第一茬，每公顷每茬采收鲜产品1千克，每年收获4～5茬。每采收一茬后都要施一定的追肥，追肥以腐熟的稀人畜粪为主，适当配以磷钾肥。生产中要保持土壤湿润。希望可以帮得上您的忙。
ab4091生产中主要以根茎分株进行无性繁殖，但也可用种子繁殖。一般进行种子繁殖在3月份播种，根茎繁殖在11月份进行。
再见小时候_7655它是一种高产量的植物，人们种植它一般都是在追求经济效益，真正把艾草当做家居植物的比较少，因而艾草的养护主要是针对集体性生产的。生长主要以采收鲜嫩株头及嫩叶为目的。需要注意分株的时间。生产中主要以根茎分株进行无性繁殖，但也可用种子繁殖。一般进行种子繁殖在3月份播种，根茎繁殖在11月份进行。选址需谨慎。畦宽1.5米左右，畦面中间高两边低似“鱼背”型，以免积水，造成病害。施肥有讲究。播种前要施足底肥，一般每667米2施腐熟的农家肥4000千克，深耕与土壤充分拦匀，排后即浇一次充足的底水。肥料有要求。 每年3月初在地越冬的根茎开始萌发，4月下旬采收第一茬，每公顷每茬采收鲜产品1千克，每年收获4～5茬。每采收一茬后都要施一定的追肥，追肥以腐熟的稀人畜粪为主，适当配以磷钾肥。
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