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2011年度国家体育总局体育哲学社会科学研究项目课题指南The Candida albicans myristoyl-CoA:protein N-myristoyltransferase gene. Isolation and... - Abstract - Europe PMC
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(PMID:1569105)
Wiegand RC
Minnerly JC
Langner CA
Duronio RJ
Myristoyl-CoA:protein N-myristoyltransferase (NMT) has recently been identified as a target for antiviral and antifungal therapy. Candida albicans is a dimorphic, asexual yeast that is a major cause of systemic fungal infections in immunosuppressed humans. Metabolic labeling studies indicate that C. albicans synthesizes one principal 20-kDa N-myristoyl-protein. The single copy C. albicans NMT gene (ca-NMT1) was isolated and encodes a 451-amino acid protein that has 55% identity with Saccharomyces cerevisiae NMT. C. albicans NMT1 is able to complement the lethal phenotype of S. cerevisiae nmt1 null mutants by directing efficient acylation of the approximately 12 endogenous N-myristoylproteins produced by S. cerevisiae. C. albicans NMT was produced in Escherichia coli, a prokaryote with no endogenous NMT activity. In vitro studies of purified E. coli-derived S. cerevisiae and C. albicans NMTs revealed species-specific differences in the kinetic properties of synthetic octapeptide substrates derived from known N-myristoylproteins. Together these data indicate that C. albicans and S. cerevisiae NMTs have similar yet distinct substrate specificities which may be of therapeutic significance.
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CitePeer Related Articles查看: 980|回复: 3
急，急，急，请各位大神帮帮忙！跪谢🙏
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哪款弯梁车坐垫下面的储物箱比较大！&&
本人最近爱上了钓鱼，想买一辆弯梁摩托，因为好多钓鱼的都是骑弯梁的，能载物，还方便，我的要求就是坐垫底下储物箱一定要大！之前看了几款，要不没有，要不就是太小，所以我想请各位有知道的告诉我下品牌和型号，小的不胜感激！
状态&&&[当前离线]
弯梁车的储物箱都小，恐怕没有你想要的。
状态&&&[当前离线]
楼上的回答准确
要大就是踏板，
状态&&&[当前离线]
弯梁座子底下最多能放两双棉手套塞两瓶矿泉水什么的，带东西的话就绑后座上吧，
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Journal Article
Parere 25 marzo 1887; Comune di Castelnuovo nel Friuli
Il Foro Italiano
Vol. 12, PARTE TERZA: GIURISPRUDENZA AMMINISTRATIVA (1887), pp. 101/102-103/104
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Stable URL: http://www.jstor.org/stable/
Page Count: 2
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