APOE Predicts Aβ but not Tau Alzheimer’s Pathology in Cognitively Normal Aging
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9.38Max Planck Institute for Chemical Physics of Solids29.47Max Planck Institute for Chemical Physics of Solids+ 435.9849.96Max Planck Institute for Chemical Physics of SolidsShow more authorsAbstractWe report on the effects of annealing on the martensitic phase transformation in the Ni-based Heusler system: Mn50Ni40Sn10 and Mn50Ni41Sn9 powder and Co50Ni21Ga32 nanoparticles. For the powdered Mn50Ni40Sn10 and Mn50Ni41Sn9 alloys, structural and magnetic measurements reveal that post-annealing decreases the martensitic transformation temperatures and increases the transition hysteresis. This might be associated with a release of stress in the Mn50Ni40Sn10 and Mn50Ni41Sn9 alloys during the annealing process. However, in the case of Co50Ni21Ga32 nanoparticles, a reverse phenomenon is observed. X-ray diffraction analysis results reveal that the as-prepared Co50Ni21Ga32 nanoparticles do not show a martensitic phase at room temperature. Post-annealing followed by ice quenching, however, is found to trigger the formation of the martensitic phase. The presence of the martensitic transition is attributed to annealing-induced particle growth and the stress introduced during quenching.Discover the world's research15+ million members100+ million publications700k+ research projects
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ArticleFull-text availableAug 2015ArticleOct 2015ArticleNov 2016ArticleFull-text availableMar 2017ArticleMay 2017Project[...]Project[...]Project[...]Project[...]ArticleOctober 2015 · We report the first study on the chemical preparation, structural characterization, and magnetic properties of Co2NiGa nanoparticles (NPs) of a single γ-phase (γ-Co2NiGa). The γ-Co2NiGa NPs were prepared by impregnation in colloidal silica followed by high temperature annealing under hydrogen atmosphere. The crystal structure of tetragonal γ-Co2NiGa was confirmed by selected area electron
and... [Show full abstract]ArticleFebruary 2017 · Combined strain and magnetization measurements on the Heusler shape-memory alloys
Ni45Co5Mn38Sb12 and Ni44Co6Mn38Sb12 give evidence for strong magneto-structural coupling. The
sample length changes up to 1% at the martensitic transformation, between a ferromagnetic, austenitic
phase at high temperatures and a weakly magnetic, low-symmetry martensitic phase at lower
temperatures. Under moderate... [Show full abstract]ArticleMay 2017 · Phase transitions and magnetic properties of shape-memory materials can be tailored by tuning the size of the constituent materials, such as nanoparticles. However, owing to the lack of suitable synthetic methods for size-controlled Heusler nanoparticles, there is no report on the size dependence of their properties and functionalities. In this contribution, we present the first chemical... [Show full abstract]ArticleMarch 2014 · In Ni-Mn-Ga ferromagnetic shape memory alloys, Co-doping plays a major role in determining a peculiar phase diagram where, besides a change in the critical temperatures, a change of number, order and nature of phase transitions (e. g., from ferromagnetic to paramagnetic or from paramagnetic to ferromagnetic, on heating) can be obtained, together with a change in the giant magnetocaloric effect... [Show full abstract]Last Updated: 20 Dec 17Conversion of alloantigen-specific CD8+ T cell anergy to CD8+ T cell priming through in vivo... - Abstract - Europe PMC
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Juyang Kim
Woon S Choi
Jae-Hee Suh
Shimon Sakaguchi
Byungsuk Kwon
[01 May ):]
Research Support, Non-U.S. Gov't, Journal Article
In this study, we investigated the effect of an agonistic mAb (DTA-1) against glucocorticoid-induced TNF receptor (GITR) in a murine model of systemic lupus erythematosus-like chronic graft-vs-host disease (cGVHD). A single dose of DTA-1 inhibited the production of anti-DNA IgG1 autoantibody and the development of glomerulonephritis, typical symptoms of cGVHD. DTA-1-treated mice showed clinical and pathological signs of acute GVHD (aGVHD), such as lymphopenia, loss of body weight, increase of donor cell engraftment, and intestinal damage, indicating that DTA-1 shifted cGVHD toward aGVHD. The conversion of cGVHD to aGVHD occurred because DTA-1 prevented donor CD8+ T cell anergy. Functionally active donor CD8+ T cells produced high levels of IFN-gamma and had an elevated CTL activity against host Ags. In in vitro MLR, anergic responder CD8+ T cells were generated, and DTA-1 stimulated the activation of these anergic CD8+ T cells. We further confirmed in vivo that donor CD8+ T cells, but not donor CD4+ T cells, were responsible for the DTA-1-mediated conversion of cGVHD to aGVHD. These results indicate that donor CD8+ T cell anergy is a restriction factor in the development of aGVHD and that in vivo ligation of GITR prevents CD8+ T cell anergy by activating donor CD8+ T cells that otherwise become anergic. In sum, our data suggest GITR as an important costimulatory molecule regulating cGVHD vs aGVHD and as a target for therapeutic intervention in a variety of related diseases.
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